ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Exploring Tyramine's Role in the Formation of Supramolecular Adducts with Nonsteroidal Anti-Inflammatory Drugs.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Pair distribution function "feat." solid-state NMR in a combined approach for structure determination of organic molecules.Communications chemistry · 2026Article
- Novel Ruthenacarborane-NSAID Conjugates.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In pharmaceutical crystal engineering, salification and co-crystallization are well-established strategies to enhance the physicochemical properties of nonsteroidal anti-inflammatory drugs (NSAIDs), which typically exhibit low aqueous solubility. This study introduces three new multicomponent crystalline systems of NSAIDs (S-naproxen, flurbiprofen, and ketoprofen) with the co-former tyramine, designed using knowledge-based methods. Additionally, a new polymorph of the diflunisal-tyramine system, synthesized via mechanochemical techniques, is reported. The new multicomponent systems were thoroughly characterized using solid-state NMR and single-crystal X-ray diffraction. Aqueous solubility tests conducted through solution
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Registered trials
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