ArticleBritish journal of clinical pharmacology2025
The tacrolimus concentration-to-dose ratio is associated with kidney function in heart transplant recipients.
Article in British journal of clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Conversion to LCP Tacrolimus Mitigates Calcineurin-Induced Nephrotoxicity in Patients After Liver Transplantation.Clinical transplantation · 2026Article
- Enhanced ocular delivery of tacrolimus via cationic nanoliposomes: Mitigating inflammation and rebalancing Th17/Treg responses in dry eye disease.Materials today. Bio · 2026Article
- The Rational Basis for Personalized Treatment Using Concentration-Guided Dosing.Therapeutic drug monitoring · 2025Review
- The tacrolimus concentration-to-dose ratio is associated with kidney function in heart transplant recipients.British journal of clinical pharmacology · 2025Article
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Authors and funding
10 authors.
Funding
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Abstract
aimHeart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus-related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration-to-dose [C
methodsThis was a retrospective study including 209 HT recipients who received an immediate-release tacrolimus formulation. The C
resultsThe distribution of the individual median C
conclusionFast tacrolimus metabolism is significantly associated with worse kidney function in HT recipients in the first 5 years post-HT when compared to recipients with intermediate and slow tacrolimus metabolism.
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