Evidence map›Paper›PMID 40104878›Full record

ArticleVeterinary medicine and science2025

Pharmacokinetics of Milbemycin Oxime in Pekingese Dogs after Single Oral and Intravenous Administration.

Ze-En Li, Ming-Hui Duan, Yan Dai, Yang-Guang Jin, Yue Liu, Yan-Ni Zhang, Xing-Ping Li, Fan Yang

Abstract read
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In one paragraph

Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ze-En LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.ORCID 0009-0002-3893-5074
Ming-Hui DuanCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Yan DaiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Yang-Guang JinCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Yue LiuCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Yan-Ni ZhangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Xing-Ping LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Fan YangCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.

Funding

Postgraduate Education Reform and Quality Improvement Project of Henan Province YJS2023AL038
6 · The paper itself

Abstract

objectiveThis study aimed to characterize the pharmacokinetic profiles of milbemycin oxime in Pekingese dogs following a single oral (PO) and intravenous (IV) dose. Six clinically healthy Pekingese dogs, with an average body weight (BW) of 4.75 kg, were included. Each dog received an IV injection of milbemycin oxime solution and PO doses of both milbemycin oxime tablets and nanoemulsion, all administered at 1 mg/kg BW.

methodsBlood samples (∼0.6 mL) were collected at various time points, and milbemycin oxime concentrations were measured using a validated high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detection. Pharmacokinetic parameters were obtained through non-compartmental analysis (NCA) using WinNonLin software.

resultsOral administration of milbemycin oxime tablets resulted in a peak concentration (C

conclusionsThese findings demonstrate that the milbemycin oxime nanoemulsion is absorbed more rapidly and completely, with significantly higher bioavailability than the tablet form. This suggests that the nanoemulsion could effectively overcome the issues of poor diffusion and low bioavailability associated with tablet formulations, positioning it as a promising alternative to traditional milbemycin oxime tablets.

Indexed as

Anti-Bacterial AgentsMacrolidesAdministration, IntravenousAdministration, OralAnimalsArea Under CurveBiological AvailabilityDogsEmulsionsFemaleInjections, IntravenousMaleTabletsAnti-Bacterial AgentsEmulsionsMacrolidesmilbemycin oximeTabletsbioavailabilitymilbemycin oximenanoemulsionPekingese dogspharmacokinetics

Identifiers

PMID40104878
PMCPMC11920723

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.