Evidence map›Paper›PMID 40104811›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Preemptive anticoagulation during antenatal pulmonary embolism diagnostics in a community setting: retrospective cohort study.

Aidan R Campbell, Cole J Florio, Grace V Heringer, Sara T Woldemariam, Scott D Casey, William B Stubblefield, Lauren M Westafer, Edward Qiao, Cydney E Middleton, Lara Zekar and 7 more

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Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Aidan R CampbellKaiser Permanente CREST Network, Pleasanton, California, USA.
Cole J FlorioKaiser Permanente CREST Network, Pleasanton, California, USA.
Grace V HeringerKaiser Permanente CREST Network, Pleasanton, California, USA.
Sara T WoldemariamDepartment of Obstetrics and Gynecology, Kaiser Permanente Oakland Medical Center, Oakland, California, USA.
Scott D CaseyKaiser Permanente CREST Network, Pleasanton, California, USA.
William B StubblefieldDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Lauren M WestaferDepartment of Emergency Medicine and Department of Healthcare Delivery and Population Science, University of Massachusetts Chan Medical School-Baystate, Springfield, Massachusetts, USA.
Edward QiaoKaiser Permanente CREST Network, Pleasanton, California, USA.
Cydney E MiddletonDepartment of Emergency Medicine, UC Davis Health, Sacramento, California, USA.
Lara ZekarDepartment of Emergency Medicine, UC Davis Health, Sacramento, California, USA.
Nachiketa GuptaThe Permanente Medical Group, Pleasanton, California, USA.
Madeline J SomersKaiser Permanente CREST Network, Pleasanton, California, USA.
Mary E ReedKaiser Permanente CREST Network, Pleasanton, California, USA.
Nareg H RoubinianKaiser Permanente Northern California Division of Research, Pleasanton, California, USA.
Ashok P PaiThe Permanente Medical Group, Pleasanton, California, USA.
Jeffrey D SperlingThe Permanente Medical Group, Pleasanton, California, USA.
David R VinsonKaiser Permanente CREST Network, Pleasanton, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Society recommendations for preemptive (or empiric) anticoagulation during antenatal pulmonary embolism (PE) diagnostics rely on expert opinion, which varies widely across guidelines. The American College of Chest Physicians (CHEST), for example, recommends preemptive anticoagulation when PE is highly suspected or when a delay in imaging is anticipated. The American College of Obstetricians and Gynecologists, however, makes no mention of preemptive anticoagulation for suspected PE in their practice bulletin on thromboembolism in pregnancy. Patterns of preemptive anticoagulation in pregnancy are unknown. Objectives: To describe the prevalence of and CHEST-based eligibility for preemptive anticoagulation in pregnancy. Methods: This retrospective cohort study was undertaken across 21 United States community hospitals from October 1, 2021 through March 30, 2023. We included pregnant adults without COVID-19 undergoing definitive diagnostic PE imaging. We used pregnancy-adapted Geneva scores to calculate pretest probability as a proxy for suspicion. Results: We included 326 patients: median age, 31.0 years; 51% were in the third trimester. Diagnostic settings included emergency departments ( Conclusion: We found rare use of preemptive anticoagulation during antenatal PE diagnostics in this imaged cohort with low PE prevalence and rapid access to diagnostic imaging. More research is needed to explore setting-specific variation in preemptive anticoagulation use.

Indexed as

anticoagulantscomputed tomography angiographyperfusion imagingpregnancypulmonary embolism

Identifiers

PMID40104811
PMCPMC11914514

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.