Evidence map›Paper›PMID 40104692›Full record

ReviewJID innovations : skin science from molecules to population health2025

Antimicrobial Peptide Signaling in Skin Diseases.

Sharan Kumar Balaji, Bhavani Balasundarasekar, Waris Muhammad Khuwaja, Keean Michael Dolan, Xintong Dong

Abstract readReview
In one paragraph

Review in JID innovations : skin science from molecules to population health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sharan Kumar BalajiDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
Bhavani BalasundarasekarDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
Waris Muhammad KhuwajaDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
Keean Michael DolanDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.
Xintong DongDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, Texas, USA.

Funding

Genetic dissection of defensin signaling in urinary tract infectionsR01DK140039 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI Xintong Dong · 2024 to 2026
$1.8M
NIDDK NIH HHS R01 DK140039
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are important innate immune molecules at microbe-host interfaces. The biophysical properties of AMPs that facilitate direct killing of microbes have been extensively reviewed. In this article, we focus on how AMPs perform immunomodulatory functions through interaction with host receptors on epithelial, immune, and neuronal cell types. We summarize the current knowledge of known AMPs in the skin, the receptors that respond to AMPs, and the downstream intracellular signaling pathways. In the end, we discuss the roles of AMP signaling systems in skin diseases.

Indexed as

Antimicrobial peptidesAtopic dermatitisGPCRsPsoriasisRosacea

Identifiers

PMID40104692
PMCPMC11914806

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.