ArticleMaterials today. Bio2025
Dual-network hydrogel loaded with antler stem cells conditioned medium and EGCG promotes diabetic wound healing through antibacterial, antioxidant, anti-inflammatory, and angiogenesis.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Selenium nanoparticle-loaded microneedle patches promote diabetic oral ulcer healing by regulating the inflammatory microenvironment through upregulation of SELENBP1-mediated mitophagy.Journal of nanobiotechnology · 2026Article
- ROS-triggered smart hydrogel adhesives for modulating the inflammatory microenvironment and promoting tendon-bone interface regeneration.International journal of pharmaceutics: X · 2026Article
- Preparation and Application of Sodium Alginate-Based Composite Hydrogels in Wound Dressings.Gels (Basel, Switzerland) · 2026Review
- A Dual-Network Injectable Hydrogel Scaffold Integrating Glycyrrhizic Acid and Acellular Fat Extracts for Synergistic Enhancement of Diabetic Wound Healing.ACS polymers Au · 2026Article
- A multifunctional EGCG/Si nanohybrid-coated 3D-printed porous scaffold for bone defect repair.Regenerative biomaterials · 2026Article
- Harnessing marine-derived materials for therapeutics innovations: Advances in biomaterials from the ocean.Materials today. Bio · 2025Review
- ROS/Glucose-Dissociable EGCG-Coated Oxygen-Supplying Nanocomposite Hydrogel for Diabetic Wound Therapy.International journal of nanomedicine · 2025Article
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Authors and funding
11 authors.
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Abstract
Diabetic wound healing is characterized by persistent inflammation, reactive oxygen species overproduction, bacterial infection, and compromised angiogenesis. In recent years, Antler Stem Cells (ASCs) have attracted attention because of their potential role in promoting wound healing by promoting cell proliferation and angiogenesis via paracrine effects. In addition, epigallocatechin gallate (EGCG), the main component of green tea, exhibits antibacterial, anti-inflammatory, and antioxidant properties. In this study, we designed and fabricated a gelatin (G)/sodium alginate (SA)-based (SA/G) dual-network hydrogel loaded with ASC-derived conditioned medium (ASC-CM) and EGCG (CEGA) that exhibited excellent swelling capacity, sustained release, and mechanical properties. Both in vitro and in vivo experiments demonstrated that CEGA hydrogels were capable of enhancing cell proliferation, promoting angiogenesis, exhibiting antibacterial properties, mitigating inflammation, and regulating macrophage polarization. These results substantiate their potential application as novel dressings for healing diabetic skin wounds.
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