ArticleMaterials today. Bio2025
Integrating melt electrowriting (MEW) PCL scaffolds with fibroblast-laden hydrogel toward vascularized skin tissue engineering.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Advancements in Functional Polymeric Scaffolds for Scar-Free Skin Regeneration.Polymer science & technology (Washington, D.C.) · 2026Review
- Hybrid SES-MEW Scaffold Strategies: A Narrative Review of Multi-Scale Fiber Architectures for Soft and Hard Tissue Engineering.Pharmaceuticals (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional (3D) skin equivalents (SEs) are promising platforms for studying skin disease or assessing the safety of skin-relevant products. Vascularization, which improves the functionality of reconstructed skin, is one of the remaining hurdles in SE production that, when successfully introduced, can widen SE applications. Here, combining porous polycaprolactone (PCL) melt electrowritten (MEW) scaffolds with fibroblast-laden methacrylated gelatin hydrogel (GelMA), we developed SEs with cellular vascular structure. The MEW scaffolds were composed of two layers: random fibers for culturing the keratinocytes to fabricate the epidermis; and well-aligned shapes filled with fibroblast-laden GelMA to mimic the dermis. Three dermal designs varying in porosities and pore sizes were compared to optimize the dermis reconstruction. Within one week, the design with bigger pore sizes achieved optimal cell distribution, penetration, and extracellular matrix (ECM) deposition. Additionally, Retinoic acid (RTA) was tested for improving ECM deposition. To mimic vasculature, we incorporated vascular grafts into the optimized SEs. These were fabricated by casting endothelial fibroblast-laden Matrigel onto small-diameter MEW-tubular structures. The versatility and reproducibility of the obtained SEs offer a robust new tool for
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