Evidence map›Paper›PMID 40104636›Full record

ReviewMaterials today. Bio2025

Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing.

Wenwen Li, Huihui Zhang, Lianglong Chen, Chaoyang Huang, Ziwei Jiang, Hai Zhou, Xinxi Zhu, Xiaoyang Liu, Zesen Zheng, Qiuyi Yu and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wenwen LiDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Huihui ZhangDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Lianglong ChenDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Chaoyang HuangDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Ziwei JiangDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Hai ZhouDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xinxi ZhuDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xiaoyang LiuDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zesen ZhengDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Qiuyi YuDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yufang HeDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yanbin GaoDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Jun MaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Lei YangDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell membrane-derived nanovesicles (NVs) have emerged as promising alternatives to extracellular vesicles (EVs) for wound healing applications, addressing the limitations of traditional EVs, which include insufficient targeting capability, low production yield, and limited drug-loading capacity. Through mechanical cell extrusion methods, NVs exhibit superior characteristics, demonstrating enhanced yield, stability, and purity compared to natural EVs. These NVs can be derived from various membrane sources, including single cell types (stem cells, blood cells, immune cells, and bacterial membranes), hybrid cell membranes and cell membranes mixed with liposomes, with each offering unique therapeutic properties. The integration of genetic engineering and surface modifications has further enhanced NV functionality, enabling precise targeting and improved drug delivery capabilities. Recent advances in NV-based therapies have demonstrated their potential across multiple biomedical applications. Although challenges persist in terms of standardization, storage stability, and clinical translation, the combination of natural cell-derived functions with artificial modification potential positions NVs as a promising platform for next-generation therapeutic delivery systems, thereby offering new possibilities in wound healing applications. Finally, we explore the challenges and future prospects of translating NV-based therapeutics into clinical practice, providing insights into the future development of this innovative approach in wound healing and tissue repair.

Indexed as

Biomimetic materialsBionanotechnologyCell membrane-derived nanovesiclesExtracellular vesiclesWound healing

Identifiers

PMID40104636
PMCPMC11914519

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.