ArticleTurkish journal of biology = Turk biyoloji dergisi2025
Metal complexes of sulfamethazine/benzoin-based Schiff base ligand: synthesis, characterization, DFT calculations, and antimicrobial activities.
Article in Turkish journal of biology = Turk biyoloji dergisi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/aim: The global rise in bacterial resistance poses a significant challenge, exacerbated by the overuse of antibacterial agents. Schiff base-metal complexes have gained attention for their potential antimicrobial properties, attributed to their unique three-dimensional structures and modes of action, such as cell wall inhibition and membrane disruption. The aim of this study was to synthesize and characterize a novel Schiff base (L) derived from sulfamethazine and benzoin, and to develop metal complexes of it with Cu Materials and methods: The compound L and its metal complexes were synthesized. The compounds were characterized with Results: The synthesized compounds (L, 1, 2, 3, 4) were tested for antibacterial and antifungal activities. Copper-based compound 1 showed the best overall antifungal activity, while zinc-based compound 3 demonstrated notable antibacterial efficacy against Conclusion: This study highlights the potential of Schiff base-metal complexes as effective antimicrobial agents in response to the growing challenge of bacterial resistance. The synthesized Schiff base (L) and metal complexes of it with Cu
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