ArticleFrontiers in veterinary science2025
Rapid quantification and PK-PD modeling of rocuronium bromide in beagles using portable mass spectrometer.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A pilot study of a novel portable mass spectrometer for rapid, simultaneous detection of multiple anesthetic drug concentrations.Frontiers in veterinary science · 2026Article
- Rapid quantification and validation of etomidate and dexmedetomidine blood concentrations in rats using a novel portable mass spectrometer.Frontiers in veterinary science · 2025Article
- Effects of bolus injection rate on the pharmacodynamics and pharmacokinetics of propofol, etomidate and sufentanil in rats.Frontiers in veterinary science · 2025Article
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Authors and funding
5 authors.
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Abstract
Monitoring rocuronium bromide (Rocur) concentrations is crucial for assessing muscle relaxation in clinical anesthesia. However, no suitable instruments are currently available. This study explores the application of a portable mass spectrometer (MS) for the rapid detection of Rocur concentrations in whole blood from beagles, aiming to support the development of individualized pharmacokinetic-pharmacodynamic (PK-PD) models. Four beagles (1-1.5 years old, 8-12 kg) received a single intravenous dose of Rocur (3 ED₅₀, 0.748 mg/kg). Neuromuscular monitoring was conducted using the train of four (TOF) ratio. Blood samples (0.1 mL) were collected at predetermined intervals and during recovery, with TOF ratios recorded at corresponding time points. Rocur concentrations in whole blood (C
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