ArticleFrontiers in surgery2025
Prognostic value of preoperative and postoperative serum CEA in colorectal signet ring cell carcinoma.
Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colorectal signet ring cell carcinoma (SRCC) is a rare and poorly prognosed tumor with limited established prognostic indicators. This study aims to investigate the prognostic value of serum carcinoembryonic antigen (CEA) in patients with colorectal SRCC. Methods: A retrospective, multicenter study was conducted to assess the association between CEA levels and survival outcomes in 942 patients with colorectal SRCC. Results: Patients exhibiting preoperative CEA (preCEA)-positivity demonstrated significantly lower cancer-specific survival (CSS) compared to those with preCEA-negativity in both Chinese and SEER datasets (5-year CSS: 27.50% vs. 48.27%, Conclusions: Both preoperative and postoperative elevation of CEA levels were associated with adverse outcomes, with preoperative CEA demonstrating particularly significant predictive value in advanced-stage tumors. These findings propose that CEA could be a valuable tool for dynamically monitoring the prognosis of colorectal SRCC patients.
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