ArticleAmerican journal of ophthalmology case reports2025
Intrastromal autologous implantation of adipose derived adult stem cells for the management of established corneal scars.
Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Adipose-Derived Stem Cells in Ophthalmic Regenerative Medicine: From Cell Replacement to Precision Engineering.Stem cell reviews and reports · 2026Review
- In Vivo Evaluation of Injected and Bioprinted Hyaluronic Acid-Based Bioink in Corneal Stromal Pocket.Macromolecular bioscience · 2026Article
- Bioartificial human corneas generated by tissue engineering. A historical and technical review.Histology and histopathology · 2026Review
- Corneal regeneration: How can we make further progress in corneal surgery with advanced therapies to avoid corneal substitution: ESCRS Binkhorst Medal Lecture 2023.Journal of cataract and refractive surgery · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To describe a case of well-documented corneal stroma transparency improvement following the intrastromal implantation of autologous adipose-derived mesenchymal stem cells (ADASC) in a keratoconic patient with established stromal scars. Observations: ADASC were isolated by elective liposuction, and a solution composed of 3x106 ADASC contained in 1mL saline was used to soak a corneal intrastromal pocket created with femtosecond laser at mid-depth. No signs of inflammation or rejection were observed. One year after surgery, we observed a complete restoration of the pre-existing corneal stroma scars, observed both clinically and by anterior segment OCT. The rest of the visual and topographic parameters did not show relevant changes except for the patient's refractive sphere. OCT showed a thin new layer of neocollagen deposited at the surgical plane. Total stroma optical density (OD) improved from 51.5 to 41.2 GSU, anterior stroma OD improved from 55.9 to 42.8 GSU, and posterior stroma OD improved from 46.9 to 39.6 GSU. Conclusions and importance: This clinical case provides new clinical evidence supporting the use of intrastromal mesenchymal stem cell implantation to solve or alleviate established corneal scars.
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Registered trials
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