Evidence map›Paper›PMID 40104204›Full record

ArticleAmerican journal of ophthalmology case reports2025

Outer retinal reflectivity and visual function loss after anatomically successful macula-off rhegmatogenous retinal detachment repair.

Ajay Kolli, Jessica Wong, Stephanie Duret, Jay M Stewart, Thomas B Connor, Austin Roorda, Joseph Carroll, Jacque L Duncan

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Current Topics in OCT Applications in Vitreoretinal Surgery.Bioengineering (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ajay KolliDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Jessica WongDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Stephanie DuretDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Jay M StewartDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Thomas B ConnorDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
Austin RoordaHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley. Berkeley, CA, USA.
Joseph CarrollDepartment of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
Jacque L DuncanDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
Advanced Technology to Study Visual Function on a Cellular ScaleR01EY023591 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUNCAN, JACQUE LYNNE, ROORDA, AUSTIN · 2014 to 2023
$11.2M
Assessing Photoreceptor Structure and Function in Normal and Diseased RetinaeR01EY017607 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Joseph Carroll · 2008 to 2026
$8.3M
Developing Cone-Dominant Retinal Disease Models as a Resource for Translational Vision ResearchU24EY029891 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI CARROLL, JOSEPH, DUNCAN, JACQUE LYNNE · 2018 to 2022
$6.6M
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY017607NEI NIH HHS R01 EY023591NEI NIH HHS U24 EY029891
6 · The paper itself

Abstract

Purpose: Rhegmatogenous retinal detachment (RRD) can cause permanent photoreceptor damage with subsequent vision loss, even after prompt repair. Here we compared photoreceptor structure in retinal areas with varying levels of residual visual function loss following anatomically successful macula-off RRD repair. Observations: Five eyes of four individuals (2 male, 2 female; ages 18-77 years) with successful macula-off RRD repair were included. Two were repaired via scleral buckle, one via vitrectomy, and two with both. Postoperative visual acuity measured 4-11 months after surgical repair ranged from 20/20 to 20/100. In each eye, areas of previously detached macula exhibited reduced or variable cone reflectivity on adaptive optics scanning light ophthalmoscopy (AOSLO) images. This was typically associated with reduced or variable inner segment/outer segment junction (IS/OS) band reflectivity on optical coherence tomography (OCT) images. Areas of the macula with reduced photoreceptor reflectivity also showed lower sensitivity on microperimetric testing. Conclusions: Despite anatomically successful repair, RRD results in photoreceptor changes, including reduced reflectivity of cone profiles and the IS/OS band that were associated with reduced macular sensitivity. As ophthalmologic imaging progresses towards higher resolution modalities, AOSLO may be useful in monitoring outcomes after RRD repair. Low cone reflectivity, cataract, high axial length, and poor visual fixation may be barriers to quantification of cone structure in this patient population.

Indexed as

Adaptive opticsOptical coherence tomographyRetinal detachment

Identifiers

PMID40104204
PMCPMC11915148

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.