Evidence map›Paper›PMID 40104021›Full record

ArticleBioactive materials2025

Multifunctional magneto-electric and exosome-loaded hydrogel enhances neuronal differentiation and immunoregulation through remote non-invasive electrical stimulation for neurological recovery after spinal cord injury.

Wubo Liu, Qiang Liu, Zeqin Li, Chunjia Zhang, Zehui Li, Han Ke, Xin Xu, Xiaoxin Wang, Huayong Du, Zuliyaer Talifu and 8 more

Abstract read
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Extracellular vesicle-based therapeutic strategies for spinal cord injury.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Wubo LiuDepartment of Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China.
Qiang LiuDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Zeqin LiChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Chunjia ZhangChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Zehui LiChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Han KeDepartment of Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China.
Xin XuDepartment of Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China.
Xiaoxin WangChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Huayong DuChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Zuliyaer TalifuChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Yunzhu PanChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Xiaoxiong WangDepartment of Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China.
Jingyun MaoCollege of Environmental and Resource Sciences, College of Carbon Neutral Modern Industry, Fujian Normal University, Fuzhou, 350007, PR China.
Feng GaoChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Degang YangChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Yan YuChina Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, 100068, PR China.
Xinyu LiuDepartment of Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China.
Jianjun LiDepartment of Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervention in the differentiation of neural stem cells (NSCs) is emerging as a highly promising approach for the treatment of spinal cord injury (SCI). However, NSCs at the injury site often suffer from low survival and uncontrolled differentiation. Whereas electrical stimulation has proven effective in regulating the fate of NSCs and promoting tissue repair, however, conventional electrical stimulation therapy has failed to be widely applied due to challenges such as invasiveness and technical complexity. To overcome these limitations, we developed a biomimetic magneto-electric hydrogel incorporating Fe

Indexed as

HUMSC-ExosMagneto-electric nanoparticlesNeuronal differentiationSpinal cord injury repairTissue engineering

Identifiers

PMID40104021
PMCPMC11919302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.