ArticleRSC advances2025
Detection of an oxidative stress metabolite associated with neurodegenerative diseases: effect of heteroatom doped antioxidant carbon dots.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Review
- Methodologies for Assessing Chemical Toxicity to Aquatic Microorganisms: A Comparative Review.Molecules (Basel, Switzerland) · 2026Review
- Carbon dots penetrating the blood-brain barrier for central nervous system nanomedicine.Theranostics · 2026Review
- Portable sensor for the detection of picric acid using fluorescent carbon dot embedded PVA film.RSC advances · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon dots (CDs) are neoteric forms of carbon nanostructures, and play a fundamental role in early diagnosis and controlling of neurological disorders (NDs). Aiming towards the detection of an oxidative stress metabolite, the present study provides an innovative strategy for developing heteroatom-doped carbon dots using tamarind as a sustainable carbon source and urea as a nitrogen dopant through a one-step hydrothermal process. This method offers a cost-effective and eco-friendly solution without compromising performance. The structural and functional properties of the synthesized CDs were characterized using advanced techniques, including fluorescence spectroscopy, UV-visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, and X-ray photoelectron spectroscopy (XPS). Antioxidant assessments revealed remarkable free-radical scavenging activity (exceeding 80% efficiency) across three independent methodologies. Furthermore, the CDs demonstrated exceptional sensitivity and selectivity in detecting oxidative stress metabolites, particularly 3-nitrotyrosine, with detection efficiency influenced by environmental pH (4.8-8.7). Biocompatibility studies using fibroblast cells confirmed their non-toxic nature, supporting their potential for biomedical applications. Collectively, these findings highlight the promise of heteroatom-doped CDs as a novel platform for detecting oxidative stress metabolites associated with neurodegenerative diseases, bridging fundamental research with real-world diagnostic advancements.
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Registered trials
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