ArticleInternational journal of ophthalmology2025
Investigation of the infection route of HIV-associated cytomegalovirus retinitis.
Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A case series: cytomegalovirus retinitis following autologous hematopoietic cell transplantation: a call for early detection and aggressive management.Frontiers in medicine · 2025Article
- Cytomegalovirus retinitis in diverse immunocompromised populations: clinical presentation, treatment outcomes, and prognostic factors.Therapeutic advances in ophthalmologyArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the etiology of ocular pathogens and to establish the various pathogens present in human immunodeficiency virus (HIV) patients with cytomegalovirus retinitis (CMVR).
methodsA total of 17 HIV-infected patients with concomitant eye disorders were enrolled. Patients were divided into CMVR group (10 patients, 18 eyes) and non-CMVR group (7 patients, 9 eyes) based on clinical manifestations and the presence of cytomegalovirus (CMV)-DNA in ocular specimens. The viral load of CMV was assessed using polymerase chain reaction in aqueous humor, vitreous fluid, and peripheral blood samples of patients in the CMVR group. Additionally, peripheral blood CD4
resultsIn the CMVR group, the CMV-DNA load in the vitreous and aqueous humor samples was substantially higher than in the peripheral blood samples (
conclusionIn HIV-associated CMVR patients, there may exist alternative, yet unidentified, infection pathways for intraocular CMV in addition to the conventional route. The substantial difference in CMV-DNA load between the eyes of most CMVR patients suggests that CMV may originate from different sources in each eye. The proportion of peripheral blood CD4
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