ArticleInternational journal of ophthalmology2025
Refractive status and histological changes after posterior scleral reinforcement in guinea pig.
Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
aimTo investigate the refractive and the histological changes in guinea pig eyes after posterior scleral reinforcement with scleral allografts.
methodsFour-week-old guinea pigs were implanted with scleral allografts, and the changes of refraction, corneal curvature and axis length were monitored for 51d. The effects of methylprednisolone (MPS) on refraction parameters were also evaluated. And the microstructure and ultra-microstructure of eyes were observed on the 9d and 51d after operation. Repeated-measures analysis of variance and one-way analysis of variance were used.
resultsThe refraction outcome of the implanted eye decreased after operation, and the refraction change of the 3 mm scleral allografts group was significantly different with control group (
conclusionAfter implantation of scleral allografts, the refraction of guinea pig eyes fluctuated from a decrease to an increase. The outcome of the scleral allografts is affected by implantation methods and the inflammatory response. Stability of the material can be improved by MPS.
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