ArticlePakistan journal of medical sciences2025
Relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia.
Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Blood Metabolomic Profiling of Systemic Responses to Dried Black Lychee in a Scopolamine-Induced Cognitive Impairment in Rats.Biology · 2026Article
- Association of oxidative stress, metacognition, and psychopathology in patients with schizophrenia: a case-control study.Frontiers in psychiatry · 2026Article
- The interplay between homocysteine, oxidative stress, and butyrylcholinesterase activity in the pathogenesis of schizophrenia.BMC psychiatry · 2025Article
- Managing Symptoms in Adolescent-Onset Schizophrenia: A Narrative Review of Therapeutic Interventions.Healthcare (Basel, Switzerland) · 2025Review
- A Randomized Controlled Trial on the Safety and Cognitive Benefits of a Novel Functional Drink from a Purple Waxy Corn Byproduct in Peri- and Postmenopausal Women.Antioxidants (Basel, Switzerland) · 2025Article
- Association between redox dysregulation and vulnerability to cognitive deficits induced by maternal immune activation.Translational psychiatry · 2025Article
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5 authors.
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Abstract
Objective: To investigate the relationship between cognitive impairment and oxidative stress markers in patients with early-onset schizophrenia(EOS). Methods: This was a retrospective study. A total of 42 patients with EOS admitted to The Eighth Hospital of Shijiazhuang from December 2021 to December 2023 and 42 healthy volunteers were included in this study and classified as the observation group and the control group. Cognitive impairment and oxidative stress markers were assessed in both groups. The Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS) Consensus Cognitive Battery(MCCB) was used to evaluate cognitive function, and the serum levels of superoxide dismutase(SOD), malondialdehyde, glutathione peroxidase(GSH-Px), catalase, homocysteine, and nitric oxide(NO) were measured. Pearson correlation analysis was conducted to clarity the relationship between cognitive function and oxidative stress markers. Results: The SOD and GSH-Px levels in the observation group were lower than in the control group, while homocysteine, catalase, malondialdehyde, and NO levels were higher in the observation group. Compared to the control group, patients in the observation group scored significantly lower for information processing speed, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition ( Conclusion: Cognitive impairment in patients with EOS appears to be associated with oxidative stress. There is a significant negative correlation between the levels of SOD and malondialdehyde and information processing speed.
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