ArticleOphthalmology science
OCT Angiography Analysis of Retinal and Choroidal Flow after Proton Beam Therapy for Choroidal Melanoma.
Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Uveal Melanoma: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the macular and peripapillary retinal and choroidal flow changes in eyes with choroidal melanoma (CM) treated with proton beam radiation therapy (PBRT) using OCT angiography (OCTA). Design: A prospective, cross-sectional, single-center study. Participants: All patients seen at the study center between 2019 and 2024 who received PBRT for CM in 1 eye ≥1 year before enrollment with best-corrected visual acuity (BCVA) >20/200, unremarkable contralateral eye, and agreed to participate. Methods: After a comprehensive eye examination, including BCVA, Optovue AngioVue was used to obtain the 4.5-mm optic disc and 6.0-mm macular OCT/OCT angiography (OCTA) images of both eyes. All vascular density (VD) measurements were obtained automatically using the OCTA software, except choriocapillaris VD, which was quantitated using ImageJ. The Wilcoxon signed-rank test was used to analyze differences in OCT/OCTA parameters between the treated and the contralateral eyes. Spearman's ρ was used to identify OCTA parameters associated with BCVA or radiation dose. A Main Outcome Measures: Foveal avascular zone (FAZ) area and perimeter, choriocapillaris and retinal (superficial and deep) capillary VD in the macula and radial peripapillary capillary (RPC) VD on OCTA; macular and retinal nerve fiber layer thickness on OCT, tumor location, laterality and size at baseline, BCVA of both eyes, PBRT dose, and duration of follow-up at enrollment. Results: Among 24 participants, OCT/OCTA parameters were significantly different in the treated eyes when compared with the contralateral eyes, including increased FAZ area and perimeter, decreased peripapillary retinal nerve fiber layer thickness and RPC VD, and decreased macular choriocapillaris VD and parafoveal and perifoveal superficial retinal plexus VD ( Conclusions: Although PBRT can affect both retinal and choroidal vascular flow in the macular and peripapillary region in eyes with CM, BCVA after PBRT seems to correlate best with the retinal vascular flow changes in the macula on OCTA and radiation dose to the fovea. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.