Evidence map›Paper›PMID 40103823›Full record

ArticleFrontiers in immunology2025

Persistent innate immune dysfunction and ZIKV replication in the gastrointestinal tract during SIV infection in pigtail macaques.

Jennifer Tisoncik-Go, Thomas B Lewis, Leanne S Whitmore, Kathleen Voss, Skyler Niemeyer, Jin Dai, Paul Kim, Kai Hubbell, Naoto Iwayama, Chul Ahrens and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jennifer Tisoncik-GoWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Thomas B LewisWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Leanne S WhitmoreDepartment of Immunology, University of Washington, Seattle, WA, United States.
Kathleen VossDepartment of Immunology, University of Washington, Seattle, WA, United States.
Skyler NiemeyerDepartment of Microbiology, University of Washington, Seattle, WA, United States.
Jin DaiDepartment of Immunology, University of Washington, Seattle, WA, United States.
Paul KimDepartment of Microbiology, University of Washington, Seattle, WA, United States.
Kai HubbellDepartment of Microbiology, University of Washington, Seattle, WA, United States.
Naoto IwayamaWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Chul AhrensWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Solomon WangariWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Robert MurnaneWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Paul T EdlefsenBiostatistics Bioinformatics and Epidemiology (BBE), Program of the Vaccine and Infectious Disease (ViDD) Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Kathryn A GuerrieroWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Michael GaleWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Deborah H FullerWashington National Primate Research Center, University of Washington, Seattle, WA, United States.
Megan A O'ConnorWashington National Primate Research Center, University of Washington, Seattle, WA, United States.

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
WaNPRC Macaca nemestrina SPF Breeding ColonyU42OD011123 · OD · UNIVERSITY OF WASHINGTON · PI Melissa R Berg, Cindy Buckmaster · 2012 to 2026
$34.4M
Urethral microbiome and non-gonococcal urethritis in men who have sex with men (MU19AI113173 · NIAID · UNIVERSITY OF WASHINGTON · PI HUGHES, JAMES P · 2014 to 2018
$14.3M
Project 2: Systems biology analyses of RHCMV/SIV and IL-15 mechanisms of immune programmingP01AI177688 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale · 2023 to 2026
$8.1M
Innate Immune Regulation of Zika Virus InfectionR01AI145296 · NIAID · UNIVERSITY OF WASHINGTON · PI COYNE, CAROLYN B, DIAMOND, MICHAEL S · 2019 to 2023
$4.1M
Evaluating risks of ZIKV co-infection in SIV-infected macaquesK01MH123258 · NIMH · UNIVERSITY OF WASHINGTON · PI O'CONNOR, MEGAN A · 2020 to 2022
$346k
NCATS NIH HHS UL1 TR000423NIAID NIH HHS HHSN272201800003CNIAID NIH HHS P01 AI177688NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI145296NIAID NIH HHS U19 AI113173NIH HHS P51 OD010425NIH HHS U42 OD011123NIMH NIH HHS K01 MH123258
6 · The paper itself

Abstract

Mosquito-borne flaviviruses, including dengue (DENV) and Zika (ZIKV) viruses, have caused widespread epidemics in areas with high HIV prevalence, partly due to the expanded geographic range of arthropod vectors. Despite the occurrence of large flavivirus outbreaks in areas with high HIV prevalence, little is known about the effects of flavivirus infection in people living with HIV (PLWH). Here, we use a pigtail macaque model of HIV/AIDS to investigate the impact of simian immunodeficiency virus (SIV)-induced immunosuppression on ZIKV replication and pathogenesis. During acute SIV infection, peripheral ZIKV cellular targets expanded and innate immune activation increased.

Indexed as

Gastrointestinal TractImmunity, InnateSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusVirus ReplicationZika VirusZika Virus InfectionAnimalsCoinfectionDisease Models, AnimalLeukocytes, MononuclearMacaca nemestrinaViremiaco-infectioninnate immunitynonhuman primatesimian immunodeficiency virus (SIV)Zika virus

Identifiers

PMID40103823
PMCPMC11913663

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.