ArticleFrontiers in medicine2025
Association of serum magnesium level with small fiber neuropathy in patients with type 2 diabetes.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The effect of oral magnesium supplementation on glycemic control and metabolic parameters in type 2 diabetes mellitus: a double-blind randomized controlled trial.Frontiers in endocrinology · 2026Trial
- Machine Learning-Based Prediction Model for Type 2 Diabetic Peripheral Neuropathy: Role of Bilateral Brachial-Ankle Pulse Wave Velocity and Anthropometric Indicators.International journal of general medicine · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: We aimed to investigate the association between serum magnesium (Mg) levels and small fiber neuropathy among patients with type 2 diabetes mellitus (T2DM). Methods: This study retrospectively collected data from patients with T2DM. Patients were divided based on the quartiles of the serum concentrations of Mg. Corneal confocal microscopy (CCM) was employed to determine the morphological parameters of corneal nerve fibers, including corneal nerve fiber length (CNFL), fiber density (CNFD), and branch density (CNBD). Pearson correlation analysis and multiple linear regression analyses were conducted to investigate the association between the serum levels of Mg and the morphological parameters of corneal nerve fibers. Results: In total, 136 patients with T2DM were enrolled in this study. All morphological parameters of corneal nerve fibers increased with the increasing quartiles of serum Mg levels. Using Pearson correlation analysis, we found a significant and positive association between the serum levels of Mg and CNFL ( Conclusion: The serum levels of Mg were positively and independently correlated with the morphological parameters of the corneal nerve among patients with T2DM. Serum Mg levels can serve as a potential biomarker for screening corneal small fiber neuropathy in patients with T2DM.
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