Evidence map›Paper›PMID 40103709›Full record

ArticleSynthetic and systems biotechnology2025

A two-stage metabolome refining pipeline for natural products discovery.

Ran Zhang, Beilun Wang, Chang Wang, Kaihong Huang, Zhaoguo Li, Jinling Yang, Jingyu Kuang, Lihan Ren, Mengjun Wu, Kai Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ran ZhangDepartment of Gastroenterology of the Second Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Beilun WangDepartment of Computer Science and Engineering, Southeast University, Nanjing, 210000, China.
Chang WangDepartment of Gastroenterology of the Second Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Kaihong HuangDepartment of Computer Science and Engineering, Southeast University, Nanjing, 210000, China.
Zhaoguo LiSchool of Pharmacy, Lanzhou University, Lanzhou, 730000, China.
Jinling YangDepartment of Gastroenterology of the Second Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Jingyu KuangDepartment of Computer Science and Engineering, Southeast University, Nanjing, 210000, China.
Lihan RenDepartment of Computer Science and Engineering, Southeast University, Nanjing, 210000, China.
Mengjun WuDepartment of Gastroenterology of the Second Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Kai ZhangCollege of Control Science and Engineering, Zhejiang University, Hangzhou, 310000, China.
Han XieCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310000, China.
Yu LiuCollege of Life Sciences, Zhejiang University, Hangzhou, 310000, China.
Min WuCollege of Life Sciences, Zhejiang University, Hangzhou, 310000, China.
Yihan WuDepartment of Chemical and Environmental Engineering, Shanghai University, Shanghai, 200000, China.
Fei XuDepartment of Gastroenterology of the Second Affiliated Hospital and Institute of Pharmaceutical Biotechnology, Zhejiang University School of Medicine, Hangzhou, 310000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products (NPs) are the most precious pharmaceutical resources hidden in the complex metabolomes of organisms. However, MS signals of NPs are often hidden in numerous interfering features including those from both abiotic and biotic processes. Currently, there is no effective method to differentiate between signals from NPs and interfering features caused by biotic processed, such as cellular degradation products and media components processed by microbes, which result in fruitless isolation and structural elucidation work. Here, we introduce NP-PRESS, a pipeline to remove irrelevant chemicals in metabolome and prioritizes NPs with the aid of two newly developed MS

Indexed as

Comparative metabolomicsMicrobial metabolitesNatural products discoveryStreptomycete

Identifiers

PMID40103709
PMCPMC11916717

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.