Evidence map›Paper›PMID 40103584›Full record

ArticleFrontiers in molecular neuroscience2025

Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament.

Elaine K Hebda-Bauer, Megan H Hagenauer, Daniel B Munro, Peter Blandino, Fan Meng, Keiko Arakawa, John D H Stead, Apurva S Chitre, A Bilge Ozel, Pejman Mohammadi and 5 more

Erratum issuedAbstract read
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In one paragraph

Article in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Elaine K Hebda-Bauer *Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Megan H Hagenauer *Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Daniel B MunroDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Peter BlandinoMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Fan MengMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Keiko ArakawaMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
John D H SteadDepartment of Neuroscience, Carleton University, Ottawa, ON, Canada.
Apurva S ChitreDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
A Bilge OzelDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Pejman MohammadiSeattle Children's Research Institute, University of Washington, Seattle, WA, United States.
Stanley J WatsonMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Shelly B FlagelMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Jun LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Huda AkilMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.

Funding

Investigating the role of Bmp4 in glial subtype specification and temperamentU01DA043098 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUDA AKIL, Jun Li · 2017 to 2026
$6.9M
Haplotype-aware models of gene and isoform expression with application to genetic studies of disease in diverse populationsR01GM140287 · NIGMS · SEATTLE CHILDREN'S HOSPITAL · PI GAMAZON, ERIC R, MOHAMMADI, PEJMAN · 2021 to 2024
$2.8M
NIDA NIH HHS U01 DA043098NIGMS NIH HHS R01 GM140287
6 · The paper itself

Abstract

Externalizing and internalizing behavioral tendencies underlie many psychiatric and substance use disorders. These tendencies are associated with differences in temperament that emerge early in development via the interplay of genetic and environmental factors. To better understand the neurobiology of temperament, we have selectively bred rats for generations to produce two lines with highly divergent behavior: bred Low Responders (bLRs) are highly inhibited and anxious in novel environments, whereas bred High Responders (bHRs) are highly exploratory, sensation-seeking, and prone to drug-seeking behavior. Recently, we delineated these heritable differences by intercrossing bHRs and bLRs (F

Indexed as

anxietyenergy metabolismeQTLhippocampuslocomotor activityRNA-Seqtemperament

Identifiers

PMID40103584
PMCPMC11913853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.