Evidence map›Paper›PMID 40103576›Full record

ArticleToxicology research2025

Thymoquinone loaded zinc oxide Nanoformulations synthesis, characterization and evaluation of their efficacy against carbon tetrachloride induced Hepatorenal toxicity in rats.

Mariam Hashim, Sumaira Anjum, Huma Mujahid, Khalid S Alotaibi, Shatha B Albattal, Heba I Ghamry, Mohamed Mohamed Soliman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariam HashimDepartment of Biotechnology, Kinnaird College for Women University, Jail Road, Lahore 54000, Pakistan.ORCID https://orcid.org/0009-0003-2795-2140
Sumaira AnjumDepartment of Biotechnology, Kinnaird College for Women University, Jail Road, Lahore 54000, Pakistan.ORCID https://orcid.org/0000-0003-2276-8785
Huma MujahidInstitute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.ORCID https://orcid.org/0009-0003-0841-3563
Khalid S AlotaibiGeneral Science and English Language Department, College of Applied Sciences, AlMaarefa University, Riyadh 71666, Saudi Arabia.ORCID https://orcid.org/0009-0000-1333-4446
Shatha B AlbattalGeneral Science and English Language Department, College of Applied Sciences, AlMaarefa University, Riyadh 71666, Saudi Arabia.ORCID https://orcid.org/0009-0009-4919-6300
Heba I GhamryNutrition and Food Science, Department of Biology, College of Science, King Khalid University, P.O. Box 960, Abha 61421, Saudi Arabia.ORCID https://orcid.org/0000-0003-1266-9708
Mohamed Mohamed SolimanClinical laboratory Sciences Department, Turabah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID https://orcid.org/0000-0001-7208-7123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymoquinone (THQ), a strong antioxidant and anti-inflammatory bioactive compound has been reported in numerous studies to prevent the hepatorenal toxicity caused by various xenobiotics. Similarly, the zinc oxide nanoparticles (ZnONPs) have been used to protect against the hepatorenal damages caused by oxidative stress due to their potent antioxidant properties. The aim of this study was to synthesize and investigate the possible protective effects of THQ, ZnONPs and THQ-loaded ZnONPs against CCl

Indexed as

antioxidanthepatorenal toxicitylipid profilingserum biomarkersThymoquinonezinc oxide nanoparticles

Identifiers

PMID40103576
PMCPMC11912352

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.