Evidence map›Paper›PMID 40103547›Full record

ArticleClinical transplantation2025

Use of Normothermic Regional Perfusion in Circulatory Death Donors for Lung Transplantation in the United States.

Jonathan E Williams, John M Trahanas, Jacob A Klapper, Caitlin Demarest, Kiran H Lagisetty, Andrew C Chang, Dennis M Lyu, David D Odell, Matthew D Bacchetta, Aaron M Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan E WilliamsDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-7316-4266
John M TrahanasDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jacob A KlapperDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-3529-1755
Caitlin DemarestDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kiran H LagisettyDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Andrew C ChangDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Dennis M LyuDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-0116-2488
David D OdellDepartment of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Matthew D BacchettaDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Aaron M WilliamsDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

Obesity Surgery Scientist Training ProgramT32DK108740 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Brigham Dimick, RANDY J SEELEY · 2016 to 2026
$2.2M
AHRQ HHS R01 HS029343NIDDK NIH HHS T32 DK108740
6 · The paper itself

Abstract

introductionUse of normothermic regional perfusion (NRP) to recover donation after circulatory death (DCD) organs demonstrates increased heart utilization with favorable outcomes. Conversely, DCD lung allograft use when NRP was employed remains controversial. This is a contemporary analysis of DCD lung recipient outcomes in which NRP was used.

methodsUtilizing the STAR-OPTN database, all adult DCD lung recipients in the United States between January 1, 2020, and June 30, 2024 were identified. NRP use was defined if the time between donor death and aortic clamp time was greater than 30 min. Recipient outcomes, including 30-, 60-, and 90-day mortality, grade-3 primary graft dysfunction (PGD), and postoperative length of stay were compared using multivariable logistic regression controlling for donor and recipient covariates. Survival analysis was performed using Cox proportional hazard modeling.

resultsOf 987 DCD lung transplants, 92 (9.4%) utilized NRP. There were no differences in recipient characteristics between direct recovery and NRP cohorts. No difference in 30-, 60-, or 90-day mortality, grade-3 PGD, or length of stay was found between cohorts. 12-month survival was equivalent.

conclusionsOutcomes between NRP lung recipients were equivalent to DCD direct recovery recipients. Thus, donor lungs may be considered for transplantation following NRP donation procedures.

Indexed as

Lung TransplantationOrgan PreservationPerfusionTissue and Organ ProcurementTissue DonorsAdultFemaleFollow-Up StudiesGraft SurvivalHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsSurvival Ratedonation after circulatory deathlung transplantnormothermic regional perfusion

Identifiers

PMID40103547
PMCPMC11925489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.