Evidence map›Paper›PMID 40103459›Full record

ArticleAnti-cancer agents in medicinal chemistry2026

Synthesis and Evaluation of Optical Properties, SHP2 Inhibitory Activity, and Cellular Imaging for Novel 2-Quinolone Derivatives.

Chun Zhang, Yuting Yang, Li-Xin Gao, Suya Gan, Jia Li, Xin Wang, Yu-Bo Zhou, Wen-Long Wang

Abstract read
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Article in Anti-cancer agents in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Discovery of Lead Compounds Targeting Transcriptional Regulation.Anti-cancer agents in medicinal chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chun ZhangSchool of Life Sciences and Health Engineering, Jiangnan University, Jiangsu, 214122, Wuxi, China.
Yuting YangSchool of Life Sciences and Health Engineering, Jiangnan University, Jiangsu, 214122, Wuxi, China.
Li-Xin GaoSchool of Life Sciences and Health Engineering, Jiangnan University, Jiangsu, 214122, Wuxi, China.
Suya GanSchool of Life Sciences and Health Engineering, Jiangnan University, Jiangsu, 214122, Wuxi, China.
Jia LiNational Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Xin WangHenan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan, 475004, China.
Yu-Bo ZhouNational Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Wen-Long WangSchool of Life Sciences and Health Engineering, Jiangnan University, Jiangsu, 214122, Wuxi, China.

Funding

Fundamental Research Funds for the Central Universities JUSRP121065High-Level Personnel Project of Jiangsu Province JSSCBS20210848National Natural Science Foundation of China 22277043, 21772068
6 · The paper itself

Abstract

introductionAlthough the development of SHP2 inhibitors has made striking progress, there is no inhibitor in clinical evaluation because of the potential side effects induced by poor drug distribution. Fluorescence imaging technology is widely used in the process of diagnosis and treatment of diseases because of the advantages of rapid imaging and non-destructive detection and might provide a new way to explore the mechanism of drug-target interactions in intact tissue.

methodsA series of 2-quinolone derivatives as fluorescent inhibitors against SHP2 were designed and synthesized, and their spectral properties and biological activities were evaluated in this report. The representative compound 8A had excellent fluorescence properties (λ

resultsMoreover, compound 8A emitted a blue signal in SHP2WT U2OS cells and inhibited the SHP2 enzyme abilities (IC

conclusionTherefore, we hope that compound 8A could act as a lead to develop novel, convenient, and bifunctional chemical tools to explore the mechanism of drug-target interactions in intact tissue and promote the integrated research progress of diagnosis and treatment of SHP2 related diseases.

Indexed as

Antineoplastic AgentsEnzyme InhibitorsFluorescent DyesOptical ImagingProtein Tyrosine Phosphatase, Non-Receptor Type 11QuinolonesCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsEnzyme InhibitorsFluorescent DyesProtein Tyrosine Phosphatase, Non-Receptor Type 11PTPN11 protein, humanQuinolones2-quinolone derivativesdrug tracingFluorescent inhibitorsmedical diagnosis.optical propertiesSHP2

Identifiers

PMID40103459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.