Evidence map›Paper›PMID 40103332›Full record

ArticleFEBS open bio2025

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response.

Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Bo CuiBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Silin TuBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Haibo LiDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhancheng ZengBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ruiqi XiaoBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jing GuoBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xiaoqi LiangCell-Gene Therapy Translational Medicine Research Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Chang LiuBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Lijie PanLaboratory Animal Center, Sun Yat-sen University, Guangzhou, China.
Wenjie ChenBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Mian GeDepartment of Anesthesiology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xiaofen ZhongBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Linsen YeDepartment of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Huaxin ChenBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Qi ZhangBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yan XuBiotherapy Centre, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0001-5653-291X

Funding

Basic Scientific Research Foundation for Young Teachers in Higher Education Institutions 82000-31610007Cultivation Project for National Natural Science Foundation of China from The Third Affiliated Hospital of Sun Yat-sen University 2023GZRPYMS02Guangdong Provincial Science and Technology Department Project 2023TQ07A963Guangzhou Municipal Science and Technology Project 202206010072Guangzhou Municipal Science and Technology Project 2023A03J0198Guangzhou Municipal Science and Technology Project 2024A03J0272Guangzhou Municipal Science and Technology Project 2025A04J5120National Key Research and Development Program of China Stem Cell and Translational Research 2022YFA1106700National Key Research and Development Program of China Stem Cell and Translational Research 2024YFA1107200National Natural Science Foundation of China 82100663National Natural Science Foundation of China 82270652National Natural Science Foundation of China 82425010Natural Science Foundation of Guangdong Province 2022A1515010654Natural Science Foundation of Guangdong Province 2023A1515010349
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is among the most common causes of cancer-related deaths worldwide. Previous studies showed that N6-methyladenosine (m

Indexed as

CarcinogenesisCarcinoma, HepatocellularEndoplasmic Reticulum StressLiver NeoplasmsMethyltransferasesAdenosineAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceMice, KnockoutAdenosineMethyltransferasesMETTL3 protein, humanMettl3 protein, mouseN-methyladenosineER stress responsehepatocarcinogenesishepatocellular carcinomam6AMETTL3

Identifiers

PMID40103332
PMCPMC12226423

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.