ReviewClinical and translational science2025
Effect of Selective Serotonin Reuptake Inhibitors on Coagulation: Fact or Fiction?
Review in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for depression and anxiety yet are associated with an increased bleeding risk. While this risk is mainly linked to the decrease in platelet serotonin content, thus abnormal platelet functions, some studies suggest an inherent effect of SSRIs on coagulation. Hence, we performed a literature review to provide an overview of the different studies assessing SSRI's effects on coagulation assays routinely used in clinical practice. A search of the PubMed database yielded 22 relevant studies. Results were inconsistent: While some studies showed minor changes in routine coagulation assays, namely, prothrombin time and activated partial thromboplastin time, the majority found no significant effects of SSRIs on coagulation tests. Then, we specifically investigated the impact of citalopram, a commonly prescribed SSRI, on the thrombin generation assay (TGA) allowing the detection of any potential procoagulant or anticoagulant effect. TGA was performed in platelet-poor plasma from 14 healthy volunteers spiked with citalopram at therapeutic (0.1 and 0.5 μM) and supratherapeutic (50 μM) concentrations. TGA parameters were not significantly changed compared to the control condition regardless of the citalopram concentration. All in all, our findings failed to demonstrate any compromised coagulation function associated with SSRI therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.