Evidence map›Paper›PMID 40103213›Full record

ArticleAutophagy2025

The Whi2-Psr1-Psr2 complex selectively regulates TORC1 and autophagy under low leucine conditions but not nitrogen depletion.

Yitao Wang, Yang Ping, Rui Zhou, Guiqin Wang, Yu Zhang, Xueyu Yang, Mingjun Zhao, Dongsheng Liu, Madhura Kulkarni, Heather Lamb and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yitao WangInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.
Yang PingInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.
Rui ZhouInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.
Guiqin WangInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.
Yu ZhangInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.
Xueyu YangInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.
Mingjun ZhaoInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.
Dongsheng LiuInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.
Madhura KulkarniW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Heather LambW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Qingwei NiuW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
J Marie HardwickW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Xinchen TengInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0002-2427-9371

Funding

Cell death pathway leading to vacuole permeabilizationR21AI183596 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HARDWICK, J. MARIE · 2024 to 2025
$444k
Conservation of programmed cell death across speciesR56AI168539 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HARDWICK, J. MARIE · 2022 to 2022
$409k
NIAID NIH HHS R21 AI183596NIAID NIH HHS R56 AI168539
6 · The paper itself

Abstract

Amino acids and ammonia serve as sources of nitrogen for cell growth and were previously thought to have similar effects on yeast. Consistent with this idea, depletion of either of these two nitrogen sources inhibits the target of rapamycin complex 1 (TORC1), leading to induction of macroautophagy/autophagy and inhibition of cell growth. In this study, we show that Whi2 and the haloacid dehalogenase (HAD)-type phosphatases Psr1 and Psr2 distinguish between these two nitrogen sources in

Indexed as

AutophagyLeucineMultiprotein ComplexesNitrogenSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMechanistic Target of Rapamycin Complex 1Transcription FactorsLeucineMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesNitrogenSaccharomyces cerevisiae ProteinsTORC1 protein complex, S cerevisiaeTranscription FactorsWhi2 protein, S cerevisiaeAutophagyCTDSPlow leucinenitrogen depletionTORC1Whi2-Psr1-Psr2

Identifiers

PMID40103213
PMCPMC12283001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.