Evidence map›Paper›PMID 40103013›Full record

ArticleJournal of dental research2025

KMT2D Regulates Tooth Enamel Development.

J-M Lee, H Jung, Q Tang, L Li, S-K Lee, J W Lee, Y Park, H-J E Kwon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Role of Genes in Dens Invaginatus: A Whole Exome Sequencing Study.International journal of clinical pediatric dentistry · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

J-M LeeDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.
H JungDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Q TangDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.
L LiDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York, Buffalo, NY, USA.
S-K LeeDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York, Buffalo, NY, USA.
J W LeeDepartment of Biological Sciences, College of Arts and Sciences, FOXG1 Research Center, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Y ParkInstitute for Myelin and Glia Exploration, Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.
H-J E KwonDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY, USA.ORCID 0000-0001-6538-6045

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Institutional Career DevelopmentKL2TR001413 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI DUBOCOVICH, MARGARITA L · 2015 to 2024
$4.2M
Advanced Training in Oral BiologyT32DE023526 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Stefan Hans-Klaus Ruhl · 2013 to 2026
$3.7M
Genomic and functional investigations of the transcriptional regulatory network of tooth enamel developmentR01DE033085 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Hyuk Jae Edward Kwon · 2023 to 2026
$2.5M
Epigenetic regulatory roles of Mll4 in palate developmentR03DE030985 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KWON, HYUK JAE EDWARD · 2021 to 2022
$319k
NCATS NIH HHS KL2 TR001413NCATS NIH HHS UL1 TR001412NIDCR NIH HHS R01 DE033085NIDCR NIH HHS R03 DE030985NIDCR NIH HHS T32 DE023526
6 · The paper itself

Abstract

Amelogenesis, the process of enamel formation, is tightly regulated and essential for producing the tooth enamel that protects teeth from decay and wear. Disruptions in amelogenesis can result in amelogenesis imperfecta, a group of genetic conditions characterized by defective enamel, including enamel hypoplasia, marked by thin or underdeveloped enamel. Mutations in the

Indexed as

AmelogenesisDental EnamelDNA-Binding ProteinsAbnormalities, MultipleAmelogenesis ImperfectaAnimalsFaceHematologic DiseasesHistone-Lysine N-MethyltransferaseMiceMice, KnockoutMicroscopy, Electron, ScanningMyeloid-Lymphoid Leukemia ProteinVestibular DiseasesX-Ray MicrotomographyDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseKmt2d protein, mouseMyeloid-Lymphoid Leukemia Proteinamelogenesiscell differentiationepitheliumgene expressionmorphogenesisodontogenesis

Identifiers

PMID40103013
PMCPMC12319650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.