SynthesisEuropean journal of medical research2025
Effectiveness of controlled decompression against conventional decompression methods for the management of severe traumatic brain injury patients: a meta-analysis.
Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Brain Shift Patterns: Upward, Lateral and Downward Herniation, Its Correlation with Clinical Patterns in Acute Intracranial Pathologies and Neurosurgical Management.The Malaysian journal of medical sciences : MJMS · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere traumatic brain injury (TBI) presents significant management challenges, with decompressive surgery being a critical intervention. This review aimed to evaluate the efficacy of controlled decompression versus conventional decompression techniques in managing severe TBI across multiple outcomes.
methodsA comprehensive search of electronic databases (PubMed Central, SCOPUS, EMBASE, Chinese national knowledge infrastructure, Cochrane trial registry, WHO trials platform) was conducted to identify studies comparing controlled decompression with conventional methods in severe TBI patients. Pooled analysis was done using a random-effects model with inverse variance technique.
resultsThirteen studies were included. Controlled decompression significantly reduced mortality (OR 0.498, 95% CI 0.321-0.773, p = 0.002), postoperative complications (OR 0.283, 95%CI: 0.205-0.390, p < 0.0001), cerebral infarction (OR 0.488, 95% CI 0.293-0.813, p = 0.006), and brain swelling (OR 0.409, 95% CI 0.252-0.661, p < 0.0001). Improvements were also observed in favorable outcomes (OR 1.822, 95% CI 1.211-2.740, p = 0.004), prognosis (OR 2.488, 95%CI 1.292-4.792, p = 0.006), and total effective rate (OR 6.549, 95% CI 1.852-23.153, p = 0.004). Minimal heterogeneities were found across outcomes, although the quality of evidence was downgraded to low due to higher risk of bias across most studies.
conclusionsControlled decompression significantly improves outcomes in severe TBI patients compared to conventional methods. Future high-quality, multicenter randomized controlled trials are recommended to confirm these findings and guide clinical practice.
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