Evidence map›Paper›PMID 40102947›Full record

ReviewStem cell research & therapy2025

The establishment and regulation of human germ cell lineage.

Honglin Yu, Ziqi Wang, Jiayue Ma, Ruoming Wang, Shuo Yao, Zhaoyu Gu, Kexin Lin, Jinlan Li, Robert S Young, Ya Yu and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Ascorbic acid enhancesFrontiers in cell and developmental biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Honglin Yu *Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, Zhejiang, China.
Ziqi Wang *Center for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, Zhejiang, China.
Jiayue MaCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, Zhejiang, China.
Ruoming WangCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, Zhejiang, China.
Shuo YaoCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, Zhejiang, China.
Zhaoyu GuCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, Zhejiang, China.
Kexin LinCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, Zhejiang, China.
Jinlan LiCollege of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu, 610041, Sichuan, China.
Robert S YoungCenter for Global Health Research, Usher Institute, University of Edinburgh, 5-7 Little France Road, Edinburgh, EH16 4UX, UK.
Ya YuCenter for Reproductive Medicine of The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.
You YuCenter for Infection Immunity, Cancer of Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. youyu@intl.zju.edu.cn.
Min JinCenter for Reproductive Medicine of The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China. min_jin@zju.edu.cn.
Di ChenCenter for Reproductive Medicine of The Second Affiliated Hospital, Center for Regeneration and Cell Therapy of Zhejiang, University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, Zhejiang, China. dichen@intl.zju.edu.cn.ORCID http://orcid.org/0000-0002-9451-9721

Funding

National Natural Science Foundation of China 32270835Natural Science Foundation of Zhejiang Province No. Z22C129553
6 · The paper itself

Abstract

The specification of primordial germ cells (PGCs) during early embryogenesis initiates the development of the germ cell lineage that ensures the perpetuation of genetic and epigenetic information from parents to offspring. Defects in germ cell development may lead to infertility or birth defects. Historically, our understanding of human PGCs (hPGCs) regulation has primarily been derived from studies in mice, given the ethical restrictions and practical limitations of human embryos at the stage of PGC specification. However, recent studies have increasingly highlighted significant mechanistic differences for PGC development in humans and mice. The past decade has witnessed the establishment of human pluripotent stem cell (hPSC)-derived hPGC-like cells (hPGCLCs) as new models for studying hPGC fate specification and differentiation. In this review, we systematically summarize the current hPSC-derived models for hPGCLC induction, and how these studies uncover the regulatory machinery for human germ cell fate specification and differentiation, forming the basis for reconstituting gametogenesis in vitro from hPSCs for clinical applications and disease modeling.

Indexed as

Cell LineageGerm CellsPluripotent Stem CellsAnimalsCell DifferentiationHumansMice

Identifiers

PMID40102947
PMCPMC11921702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.