Evidence map›Paper›PMID 40102946›Full record

ArticleCritical care (London, England)2025

ICU mortality of post-myocardial infarction ventricular septal defect complicated by cardiogenic shock: a retrospective multicentric cohort.

Levi-Dan Azoulay, François Bagate, Clément Delmas, Sylvie Paulus, Nicolas Mongardon, Osama Abou-Arab, Pierre Squara, Michel Habis, Hélène Nougue, Tristan Morichau-Beauchant and 12 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Levi-Dan Azoulay *Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Service de Médecine Intensive Réanimation, 1 rue Gustave Eiffel, 94 010, Créteil, France.
François Bagate *Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Service de Médecine Intensive Réanimation, 1 rue Gustave Eiffel, 94 010, Créteil, France. francois.bagate@aphp.fr.
Clément DelmasHôpital Rangueil, Unité de soins intensifs de Cardiologie, Toulouse, France / Université Paul Sabatier, Toulouse, France.
Sylvie PaulusHospices Civils de Lyon, Hôpital Louis Pradel, Service d'Anesthésie-Réanimation du Pôle Est, F-69500, Bron, France.
Nicolas MongardonUniversité Paris Est Créteil, INSERM, IMRB, F-94010, Créteil, France.
Osama Abou-ArabDépartement D'anesthésie-Réanimation, Hôpital Universitaire d'Amiens, Amiens, France.
Pierre SquaraCMC Ambroise Paré, Service de Réanimation, Neuilly-sur-Seine, France.
Michel HabisCMC Parly 2, Service de Réanimation Cardio-Vasculaire, Le Chesnay, France.
Hélène NougueAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service d'Anesthésie-Réanimation, Paris, France.
Tristan Morichau-BeauchantCentre Cardiologique Du Nord, Intensive Care Unit, 93200, St-Denis, France.
Antoine KimmounCentre hospitalier universitaire De Nancy Brabois, Service de Médecine Intensive Réanimation, Vandœuvre-lès-Nancy, France.
Aurélien SeemannInstitut du Cœur Saint-Gatien, Unité de Soins Intensifs Cardiovasculaire, Tours, France.
Costin RaduAssistance Publique-Hôpitaux de Paris, Hôpitaux Universitaire Henri Mondor, Service de Chirurgie Cardiaque, Université Paris-Est Creteil, Créteil, Paris, France.
Quentin de RouxUniversité Paris Est Créteil, INSERM, IMRB, F-94010, Créteil, France.
Henri Treille de GrandsaigneHôpital Rangueil, Unité de soins intensifs de Cardiologie, Toulouse, France / Université Paul Sabatier, Toulouse, France.
Jean-Luc FellahiHospices Civils de Lyon, Hôpital Louis Pradel, Service d'Anesthésie-Réanimation du Pôle Est, F-69500, Bron, France.
Christophe BeylsDépartement D'anesthésie-Réanimation, Hôpital Universitaire d'Amiens, Amiens, France.
Bernard CholleyAssistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service d'Anesthésie-Réanimation, Paris, France.
Thomas KleinCentre Cardiologique Du Nord, Intensive Care Unit, 93200, St-Denis, France.
Antoine GailletAssistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Service de Médecine Intensive Réanimation, 1 rue Gustave Eiffel, 94 010, Créteil, France.
Armand Mekontso DessapAssistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Service de Médecine Intensive Réanimation, 1 rue Gustave Eiffel, 94 010, Créteil, France.
French PMI-VSD-Shock Study Group (FPSG)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePost myocardial infarction ventricular septal defect (PMI-VSD) complicated by refractory cardiogenic shock is associated with an extremely high mortality rate. We sought to evaluate the factors associated with in-ICU mortality in patients with PMI-VSD-related cardiogenic shock.

methodsPatients with PMI-VSD complicated by cardiogenic shock, admitted in 10 French tertiary centers between 2008 and 2022, were retrospectively included. The primary outcome was in-ICU mortality. The timing of surgery was classified as early (≤ 7 days) or late (> 7 days). Multivariable analysis was performed to identify the variables associated with in-ICU mortality.

resultsA total of 138 patients were included (mean age 70 (± 10) years, female sex 54%). Of these, 116 patients (84%) received MCS, including 43 patients (31%) with VA-ECMO. VSD surgical closure was performed in 93 patients (67%, 60 early, 33 late). Only 2 patients had percutaneous closure without surgical repair. A total of 84 patients (61%) died. The type of surgical management strategy was significantly associated with in-ICU mortality (no surgery, 100%; early surgery, 45%; late surgery, 27%; p

conclusionDelayed VSD closure is associated with improved outcomes in PMI-VSD complicated by cardiogenic shock.

trial registration#CE SRLF 19-34, #CNIL MR004 2224973, retrospectively registered 04 July 2019.

Indexed as

Heart Septal Defects, VentricularHospital MortalityIntensive Care UnitsMyocardial InfarctionShock, CardiogenicAgedAged, 80 and overCohort StudiesFemaleFranceHumansMaleMiddle AgedRetrospective StudiesCardiogenic shockExtra corporeal membrane oxygenationMechanical circulatory supportMechanical complicationMyocardial infarctionSurgical timingVentricular septal defect

Identifiers

PMID40102946
PMCPMC11921731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.