Evidence map›Paper›PMID 40102931›Full record

ArticleStem cell research & therapy2025

Enhancing myelinogenesis through LIN28A rescues impaired cognition in PWMI mice.

Xuan Wu, Zhechun Hu, Huimin Yue, Chao Wang, Jie Li, Yinxiang Yang, Zuo Luan, Liang Wang, Ying Shen, Yan Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuan WuCenter of Stem Cell and Regenerative Medicine, and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Zhechun HuSchool of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310058, China.
Huimin YueDepartment of Neurology of the First Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, 310027, China.
Chao WangDepartment of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jie LiCenter of Stem Cell and Regenerative Medicine, and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Yinxiang YangDepartment of Pediatrics, the Sixth Medical Center of PLA General Hospital, Beijing, 10048, China.
Zuo LuanDepartment of Pediatrics, the Sixth Medical Center of PLA General Hospital, Beijing, 10048, China.
Liang WangDepartment of Neurology of the Second Affiliated Hospital and Department of Human Anatomy, Histology and Embryology, System Medicine Research Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Ying ShenInternational Institutes of Medicine, Department of Neurology, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China.
Yan GuCenter of Stem Cell and Regenerative Medicine, and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. guyan2015@zju.edu.cn.ORCID http://orcid.org/0000-0001-5562-6279

Funding

China National Funds for Distinguished Young Scientists 32225021National Key Research and Development Program of China 2017YFA0104200National Natural Science Foundation of China 32071021
6 · The paper itself

Abstract

backgroundIn premature newborn infants, preterm white matter injury (PWMI) causes motor and cognitive disabilities. Accumulating evidence suggests that PWMI may result from defected differentiation of oligodendrocyte precursor cells (OPCs) and impaired maturation of oligodendrocytes. However, the underlying mechanisms remain unclear.

methodsUsing RNAscope, we analyzed the expression level of RNA-binding protein LIN28A in individual OPCs. Knockout of one or both alleles of Lin28a in OPCs was achieved by administrating tamoxifen to NG2

resultsWe found that the expression of Lin28a was decreased in OPCs in a PWMI mouse model. Knockout of one or both alleles of Lin28a in OPCs postnatally resulted in reduced OPC differentiation, decreased myelinogenesis and impaired cognitive functions. Supplementing LIN28A in OPCs postnatally was able to promote OPC differentiation and enhance myelinogenesis, thus rescuing the cognitive functions in PWMI mice.

conclusionOur study reveals that LIN28A is critical in regulating postnatal myelinogenesis. Overexpression of LIN28A in OPCs rescues cognitive deficits in PWMI mice by promoting myelinogenesis, thus providing a potential strategy for the treatment of PWMI.

Indexed as

Myelin SheathRNA-Binding ProteinsAnimalsAnimals, NewbornCell DifferentiationCognitionDisease Models, AnimalMiceMice, KnockoutOligodendrocyte Precursor CellsOligodendrogliaLin-28 protein, mouseRNA-Binding ProteinsLIN28AOligodendrocyteOligodendrocyte precursor cellsPreterm white matter injury

Identifiers

PMID40102931
PMCPMC11921748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.