Evidence map›Paper›PMID 40102928›Full record

ArticleJournal of neuroengineering and rehabilitation2025

Therapeutic and orthotic effects of an adaptive functional electrical stimulation system on gait biomechanics in participants with stroke.

Ruxin He, Yiqun Dong, You Li, Manxu Zheng, Shenghui Peng, Raymond Kai-Yu Tong, Rong Song

Abstract read
In one paragraph

Article in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. NeuroSkinSensors (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruxin HeGuangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, Guangdong, China.
Yiqun DongGuangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, Guangdong, China.
You LiGuangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, Guangdong, China.
Manxu ZhengDepartment of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Shenghui PengDepartment of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Raymond Kai-Yu TongDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, 999077, China. kytong@cuhk.edu.hk.
Rong SongGuangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, Guangdong, China. songrong@mail.sysu.edu.cn.

Funding

Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument 2020B1212060077Guangzhou Science and Technology Research Program 2024B03J1329National Natural Science Foundation of China 52105305National Natural Science Foundation of China U21A20136Natural Science Foundation of Guangdong Province 2020A1515011292
6 · The paper itself

Abstract

backgroundIn recent years, functional electrical stimulation (FES) has become a common intervention for stroke survivors to correct foot drop and improve gait biomechanics. While the orthotic effects of adaptive FES systems were well-documented, the center of pressure (COP) symmetry has been largely neglected. Furthermore, the long-term therapeutic effects of adaptive FES systems on gait biomechanics have received less attention.

methodsThis study applied a timing- and intensity-adaptive functional electrical stimulation system for evaluation and training tests to address these limitations. In the evaluation test, eight participants with chronic stroke walked under three FES conditions: no stimulation (NS), adaptive FES to the tibialis anterior (SA-ILC SCS), and hybrid adaptive FES to the tibialis anterior and the gastrocnemius (SA-ILC DCS). Nine healthy subjects walked under the NS condition as the control group. In the training test, two participants with stroke took part in a 21-day training session under the SA-ILC DCS condition.

resultsThe results showed that the COP symmetry of participants with stroke in the SA-ILC SCS condition tended to improve compared to the NS condition, while the SA-ILC DCS condition showed significant improvement, approaching that of healthy subjects. After the 21-day treatment period, there was a tendency for improvement in the knee-ankle angle, anterior ground reaction force, and COP symmetry of both participants with stroke without assistance.

conclusionThe observed improvements can be attributed to the hybrid adaptive FES targeting the tibialis anterior and gastrocnemius muscles. This study demonstrates that the adaptive FES system offers promising walking assistance capabilities and significant clinical therapeutic potential.

trial registrationEthics Committee of Zhujiang Hospital, Southern Medical University, 2022-KY-149-01. Registered 29 September 2022.

Indexed as

Electric Stimulation TherapyGaitGait Disorders, NeurologicOrthotic DevicesStrokeStroke RehabilitationAdultAgedBiomechanical PhenomenaFemaleHumansMaleMiddle AgedMuscle, SkeletalCenter of pressureFunctional electrical stimulationGait symmetryHemiplegic gaitOrthotic effectStrokeTherapeutic effect

Identifiers

PMID40102928
PMCPMC11921576

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.