Evidence map›Paper›PMID 40102775›Full record

ArticleBMC microbiology2025

Cellulase enhancing rumen microbiome of Tan sheep indicates plastic responses to seasonal variations of diet in the typical steppe.

Hairen Shi, Pei Guo, Zhen Wang, Jieyan Zhou, Meiyue He, Liyuan Shi, Xiaojuan Huang, Penghui Guo, Zhaoxia Guo, Yuwen Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hairen ShiState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.ORCID 0000-0002-1100-8353
Pei GuoState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.
Zhen WangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.
Jieyan ZhouState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.
Meiyue HeState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.
Liyuan ShiState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.
Xiaojuan HuangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.
Penghui GuoState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.
Zhaoxia GuoState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.
Yuwen ZhangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China.
Fujiang HouState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Technology Research Center for Ecological Restoration and Utilization of Degraded Grassland in Northwest China, College of Pastoral Agriculture Science and Technology, National Forestry and Grassland Administration, Lanzhou University, Lanzhou, 730020, China. cyhoufj@lzu.edu.cn.ORCID 0000-0002-5368-7147

Funding

National Key Research and Development Plan 2021YFD1300504National Natural Science Foundation of China U21A20242NSFC Projects of International Cooperation and Exchanges 32161143028Program for Innovative Research Team in University IRT17R50Scientific and technological support project for grassland ecological restoration in Gansu Province 2022002
6 · The paper itself

Abstract

backgroundClimate and geographical changes significantly influence food availability and nutrient composition over time and space, Which in turn affects the selection of microbial communities essential for maintaining gastrointestinal homeostasis and facilitating dietary adaptation. Therefore, it is essential to understand the specific responses of the gut microbiota to dietary and seasonal variations in order to improve animal conservation strategies based on solid scientific knowledge.

resultsIn summer, due to the higher nutritional quality of forage, Tan sheep exhibited enhanced forage degradation and fermentation. This was reflected by increased populations of key rumen bacteria, including Bacteroidetes, Prevotella_1, Prevotellaceae_UCG-003, Ruminococcus_1, Saccharofermentans, and Ruminococcaceae_UCG-014. Supplementation with cellulase further facilitated these processes, optimizing the utilization of available nutrients. In contrast, during winter, when the nutritional quality of forage decline, we observed lower indicators of forage degradation and fermentation in Tan sheep. Additionally, there was a significant increase in the Firmicutes/Bacteroidetes ratio, microbial diversity, microbial interactions, and metabolic activity.

conclusionsThe rumen microbiota adapts to enhance the breakdown of forage biomass and maintain energy balance during periods of inadequate nutritional value. Supplementing the diet with cellulase during these times can help mitigate the reduced digestibility associated with low-quality forage. This study highlights the dynamic adaptation of the rumen microbiota to seasonal variations in forage quality and emphasizes the potential benefits of cellulase supplementation in supporting rumen function and improving animal performance under varying environmental conditions.

Indexed as

BacteriaCellulaseDietGastrointestinal MicrobiomeRumenAnimal FeedAnimalsFermentationSeasonsSheepCellulaseCellulaseMicrobiomeRuminantSeason

Identifiers

PMID40102775
PMCPMC11917088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.