ArticleBMC pediatrics2025
Correlation between hepatitis B surface antibody (anti-HBs) in maternal blood and cord blood in newborn: a study on transplacental acquired maternal antibody.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHepatitis B Virus infection is a global health problem. Transplacental maternal antibodies can protect the infant early in life from infection.
objectivesThis study investigates the correlation between maternal and infant Hepatitis B surface antibodies (anti-HBs) in pairs.
methodsThis cross-sectional study measured anti-HBs in paired mother-infant samples. Blood samples were taken from the mother 3 h before delivery and from the newborn immediately after birth by cord blood, and they were then examined for anti-HBs using the Chemiluminescent Microparticle Immunoassay.
resultsTransplacental transfer of maternal anti-HBs was analyzed in 79 mother-infant pairs. Seventeen mothers (21.5%) had positive anti-HBs and all cord blood of newborns from these mothers had anti-HBs detected. Overall, there were 44 (55.7%) newborn blood cords that were positive for anti-HBs. The geometric mean of anti-HBs cord blood titers in newborns with maternal anti-HBs titers < 10, ≥10, ≥ 100, and ≥ 1,000 mIU/mL were 52.42, 193.83, 437.12, and ≥ 1,000 mIU /mL respectively. This study showed a significant correlation in anti-HBs between mother and infant cord blood (r = 0.863; p < 0,001).
conclusionsAnti-HB antibodies measured in mother and infant cord blood were strongly correlated, demonstrating efficient transplacental antibody transfer to protect infants against Hepatitis B infection. Hepatitis B vaccination is required for mothers to obtain immunogenicity and babies to receive hepatitis B vaccination on time.
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