Evidence map›Paper›PMID 40102763›Full record

Trial reportBMC anesthesiology2025

Midazolam premedication facilitates mask ventilation in children during propofol induction of anesthesia: a randomized clinical trial.

Rafet Yarimoglu, Betul Basaran, Tayfun Et, Aysegul Bilge, Muhammet Korkusuz

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05368441 (Effect of Midazolam Premedication on Mask Ventilation Difficulty During General Anesthesia Induction in Children), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05368441 phase4completednot on this map

Effect of Midazolam Premedication on Mask Ventilation Difficulty During General Anesthesia Induction in Children: A Randomized Clinical Study

TypeinterventionalSponsorKaraman Training and Research HospitalRan2022 to 2022Enrolled120ConditionsAnesthesia ComplicationArmsMidazolam, Saline
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rafet YarimogluDepartment of Anesthesiology and Reanimation, Karaman Training and Research Hospital, Universite District. 1984 Street, Number:1, Karaman, Turkey. drrafety@gmail.com.
Betul BasaranDepartment of Anesthesiology and Reanimation, Karaman Training and Research Hospital, Karamanoglu Mehmetbey University, Karaman, Turkey.
Tayfun EtDepartment of Anesthesiology and Reanimation, Karaman Training and Research Hospital, Karamanoglu Mehmetbey University, Karaman, Turkey.
Aysegul BilgeDepartment of Anesthesiology and Reanimation, Karaman Training and Research Hospital, Karamanoglu Mehmetbey University, Karaman, Turkey.
Muhammet KorkusuzDepartment of Anesthesiology and Reanimation, Karaman Training and Research Hospital, Karamanoglu Mehmetbey University, Karaman, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMask ventilation is the most widely used method to provide ventilation during anesthesia induction. Appropriate head and neck positions, exaggerated jaw lifts, two-hand and two-person ventilation, and the use of oral or nasal airways can facilitate mask ventilation. Neuromuscular blockers and premedication drugs such as midazolam and dexmedetomidine have also been proposed to facilitate mask ventilation. The hypothesis of this study was that midazolam premedication would facilitate mask ventilation in children.

methodsChildren aged 2-10 years were randomized into two groups. The midazolam group (Group M) received an intravenous dose of midazolam premedication (0.1 mg/kg, maximum dose 3 mg), and the control group received an intravenous dose of saline of the same volume (Group C). The primary outcome of the study was to examine the effect of midazolam premedication on mask ventilation in children, using the Han mask grading scale.

resultsThe data of 120 children were analyzed (n = 60 in Group M, n = 60 in Group C). According to the Han mask grading scale, the scores of the patients in the midazolam group were significantly lower than those of the control group. The distribution of Han scores was significantly different between the groups (p < 0.001). In the midazolam group, 93.3% of the children had a Han score of 1 and 6.7% had 2, and in the control group, 60% had a score of 1, and 40% had 2. In the subgroup analysis of overweight children, a Han score of 1 was determined in 91.7% of the midazolam group and 61.1% of the control group (p = 0.03).

conclusionIn conclusion, the results of this clinical research demonstrated that midazolam premedication improves mask ventilation in children during general anesthesia induction. The findings also showed that the effect of midazolam in facilitating mask ventilation was similar in overweight children. CLINICAL

trial registrationThe study was registered in clinicaltrials.gov (trial ID: NCT05368441 on 10/05/2022).

Indexed as

Anesthetics, IntravenousHypnotics and SedativesMasksMidazolamPreanesthetic MedicationPremedicationPropofolRespiration, ArtificialChildChild, PreschoolFemaleHumansMaleAnesthetics, IntravenousHypnotics and SedativesMidazolamPropofolAirway managementAnesthesia, generalMidazolamPediatricsPremedicationVentilation

Identifiers

PMID40102763
PMCPMC11917019

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.