Evidence map›Paper›PMID 40102731›Full record

ArticleBMC cardiovascular disorders2025

Prevalence and determinants of pulmonary hypertension in rheumatic heart disease patients at university of Gondar comprehensive specialized hospital: a retrospective study from 2018 to 2023.

Fikadu Alemiye Molla, Desalew Getahun Ayalew, Hailemaryam Alemu Astatk, Abebe Worku Teshager, Gebrehiwot Lema Legesse, Daniel Belay Agonafir, Shibabaw Fentahun, Belete Sisay Assefa, Tilahun Nega Godada, Deresse Abebe Gebrehana and 1 more

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Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Fikadu Alemiye MollaDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia. fkadualemye@gmail.com.
Desalew Getahun AyalewDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.
Hailemaryam Alemu AstatkDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.
Abebe Worku TeshagerDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.
Gebrehiwot Lema LegesseDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.
Daniel Belay AgonafirDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, Wachemo University, Hossana, Ethiopia.
Shibabaw FentahunDepartment of Internal medicine, Menelik ll Comprehensive specialized Hospital, Addis Ababa, Ethiopia.
Belete Sisay AssefaDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.
Tilahun Nega GodadaDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.
Deresse Abebe GebrehanaDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.
Abilo TadesseDepartment of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMost Rheumatic heart disease patients present with advanced disease and complications, pulmonary hypertension being one of the main complications. The presence of pulmonary hypertension is independently associated with increased pre-operative and perioperative morbidity and mortality in RHD patients. There are only few studies that showed the magnitude of pulmonary hypertension in RHD patients. This study was done to know the magnitude and predictors of PH in RHD patients so that early identification and intervention can be done for those at risk to develop PH.

methodsAn institution-based retrospective study was conducted by reviewing medical records of patients at adult echocardiographic unit from September, 2018 to September, 2023. Systolic PAP > 35mmHg using 2D echocardiography was used to diagnose pulmonary hypertension. Bi-variable logistic regression analysis followed by multivariable logistic regression analysis was done using SPSS statistics 25. P value < 0.05 and 95% CI was used to determine significant association.

resultA total of 230 RHD patients were included during the study period between September 2018 and September 2023. Most patients were below the age of 35 years (68.3%) with median age of 28 years and interquartile range of 21 to 38 years. Among the study participants 72.2% were females and 67% of them were rural residents. PH prevalence among RHD patients was found to be 77.4% (95% CI: 71.4%, 82.6%). Most patients (51.3%) had severe PH (≥ 60mmHg), whereas Mild PH (36-44mmHg) was 7.4% and moderate PH (45-59mmHg) was 18.7%. PH was found to have significant association with severe MS (AOR = 5.31, 95%CI: 1.87, 15.06), moderate to severe MR (AOR = 2.68, 95% CI: 1.05, 6.84), NYHA functional class III and IV (AOR = 2.60, 95% CI: 1.01, 6.68) and Diuretics use (AOR = 4.43, 95% CI: 1.33, 14.70).

conclusionThe prevalence of PH among rheumatic heart disease patients in this study was high. Moderate to severe MR, severe MS, NYHA class III and IV, and diuretics use were significantly associated with PH. Expanding surgical intervention to address this patients is needed to decrease PH prevalence and morbidity and mortality associated with it.

Indexed as

Hospitals, SpecialHospitals, UniversityHypertension, PulmonaryRheumatic Heart DiseaseAdultFemaleHumansMaleMiddle AgedPrevalenceRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsYoung AdultEthiopiaFactorsPrevalencePulmonary hypertensionRheumatic heart diseaseValvular heart disease

Identifiers

PMID40102731
PMCPMC11916979

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.