Evidence map›Paper›PMID 40102695›Full record

ArticleThe Gerontologist2025

Caregiver Assessment of Socioemotional Functioning in People Living With Neurodegenerative Disease (Part 1): Construct Validity of a New Measure.

Marcela C Otero, Casey K Brown, Kevin J Grimm, Elizabeth A Ascher, James J Casey, Joel H Kramer, Robert W Levenson

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Gerontologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Marcela C OteroDepartment of Psychology, University of California, Berkeley, Berkeley, California, USA.ORCID 0000-0003-2280-4555
Casey K BrownDepartment of Psychology, Georgetown University, Washington D.C., USA.ORCID 0000-0002-1827-7521
Kevin J GrimmDepartment of Psychology, Arizona State University, Tempe, Arizona, USA.
Elizabeth A AscherDepartment of Psychology, University of California, Berkeley, Berkeley, California, USA.
James J CaseyDepartment of Psychology, University of California, Berkeley, Berkeley, California, USA.
Joel H KramerUniversity of California, San Fransisco, San Fransisco, California, USA.
Robert W LevensonDepartment of Psychology, University of California, Berkeley, Berkeley, California, USA.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BRUCE L MILLER · 2002 to 2026
$67.2M
EMOTION AND AGE--REACTION, REGULATION AND UNDERSTANDINGR37AG017766 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVENSON, ROBERT WAYNE · 2000 to 2009
$3.7M
Interpersonal Emotion Regulation in Neurodegenerative Disease: Pathways to Caregiver HealthR00AG073617 · NIA · GEORGETOWN UNIVERSITY · PI BROWN, CASEY LEIGH · 2022 to 2025
$1.2M
Department of Veterans Affairs Office of Academic Affiliations Advanced Fellowship Program in Mental Illness Research and TreatmentNIA NIH HHS P01 AG019724NIA NIH HHS P01AG019724NIA NIH HHS R00 AG073617NIA NIH HHS R37 AG017766NIH HHS R37AG017766the VISN 21 MIRECC
6 · The paper itself

Abstract

BACKGROUND AND

objectivesNeurodegenerative diseases cause socioemotional changes that are commonly measured using laboratory-based assessments. However, these assessments can be labor-, cost-, and time-intensive. We aim to establish the psychometric properties of a novel informant-rated measure, the Caregiver Assessment of Socioemotional Functioning (CASEF). RESEARCH DESIGN AND

methodsUsing 3 independent samples including 366 informal caregivers and their 366 care recipients with a variety of neurodegenerative diseases and 240 neurotypical individuals, we conducted exploratory and confirmatory factor analyses to establish the structural validity of the CASEF. Additionally, to establish convergent validity, we compared caregiver reports of socioemotional functioning to care recipients' objective performance on a variety of laboratory measures of socioemotional functioning.

resultsThe CASEF captured multiple aspects of care recipients' socioemotional functioning, including the ability to (a) generate negative emotional responses (negative emotional reactivity), (b) generate positive emotional responses (positive emotional reactivity), (c) recognize others' emotions (emotion recognition), and (d) control emotional responses (emotion regulation). Each factor was associated with a corresponding laboratory-based measure, except for emotion regulation, which instead corresponded to a clinician-rated measure of care recipient disinhibition. DISCUSSION AND IMPLICATIONS: Findings suggest the CASEF is a psychometrically sound informant-report measure of socioemotional functioning in people living with neurodegenerative diseases and may be a valuable tool for identifying specific socioemotional impairments in the context of neurodegenerative disease.

Indexed as

CaregiversEmotionsNeurodegenerative DiseasesAdultAgedAged, 80 and overFactor Analysis, StatisticalFemaleHumansMaleMiddle AgedPsychometricsReproducibility of ResultsSurveys and QuestionnairesAlzheimer’s diseaseCaregiversFrontotemporal dementiaInformant-reportsMeasurement development

Identifiers

PMID40102695
PMCPMC12048799

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.