Evidence map›Paper›PMID 40102590›Full record

ArticleInternational journal of obesity (2005)2025

Serum secreted EMC10 (scEMC10) levels are inversely associated with metabolically active brown adipose tissue in humans.

Qing Miao, Yahao Wang, Qiongyue Zhang, Wei Wu, Yifei Yu, Fangfang Zeng, Yehong Yang, Chuantao Zuo, Yihui Guan, Chong Wee Liew and 3 more

Abstract read
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In one paragraph

Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qing Miao *Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. miaoqing@huashan.org.cn.
Yahao Wang *Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Qiongyue Zhang *Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Wei WuDepartment of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yifei YuDepartment of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Fangfang ZengDepartment of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Yehong YangDepartment of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Chuantao ZuoPET Center & Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0002-8856-7217
Yihui GuanPET Center & Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Chong Wee LiewDepartment of Physiology & Biophysics, University of Illinois at Chicago, Chicago, IL, USA.
Matthias BlüherHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.ORCID 0000-0003-0208-2065
Yiming LiDepartment of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Xuanchun WangDepartment of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. wangxch@fudan.edu.cn.ORCID 0000-0003-2980-4363

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesSecreted endoplasmic reticulum membrane complex subunit 10 (scEMC10) has been implicated in obesity in mice and humans. In this study, the associations of serum scEMC10 levels with thermoneutrality-modulated brown adipose tissue (BAT) activity and thyroid hormone (TH)-dependent thermogenesis were investigated in humans. SUBJECTS/

methodsSerum scEMC10 levels were measured in participants from multiple cohorts using enzyme-linked immunosorbent assay, including participants with or without active BAT determined by PET-CT scanning, participants with positive BAT before and after thermoneutrality, and patients with hyperthyroidism before and after anti-thyroid drug (ATD) treatment. The difference in serum scEMC10 between participants with positive or negative BAT, and the changes of serum scEMC10 in participants with positive BAT before and after thermoneutrality and in patients with Grave's disease-caused hyperthyroidism before and after ATD treatment were determined.

resultsPET-CT scan with

conclusionsSerum scEMC10 levels are inversely associated with BAT activity in humans.

Indexed as

Adipose Tissue, BrownThermogenesisAdultAgedFemaleHumansHyperthyroidismMaleMiddle AgedPositron Emission Tomography Computed TomographyThyroid HormonesThyroid Hormones

Identifiers

PMID40102590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.