Evidence map›Paper›PMID 40102486›Full record

ArticleNature communications2025

An epidermal serine sensing system for skin healthcare.

Ying Yuan, Bowen Zhong, Xiaokun Qin, Hao Xu, Zhexin Li, Linlin Li, Xiaofeng Wang, Wenxuan Zhang, Zheng Lou, Yongming Fan and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
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  3. Article
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  7. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Flexible humidity sensors for diverse applications.Microsystems & nanoengineering · 2025
    Review
  12. Article
  13. Article
  14. Smart Hydrogels in Wearable Electronics for Wound Treatments.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  15. Article
  16. Article
  17. Artificial Nervous Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ying Yuan *State Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China.
Bowen Zhong *State Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-9365-895X
Xiaokun QinState Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China.
Hao XuState Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China. haoxu19@semi.ac.cn.
Zhexin LiState Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China.
Linlin LiState Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China.
Xiaofeng WangState Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China.
Wenxuan ZhangState Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China.
Zheng LouState Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China. zlou@semi.ac.cn.ORCID http://orcid.org/0000-0001-5744-3759
Yongming FanKey Laboratory of Lignocellulosic Chemistry, College of Material Science and Technology, Beijing Forestry University, Beijing, China. fanym@bjfu.edu.cn.
Lili WangState Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China. liliwang@semi.ac.cn.ORCID http://orcid.org/0000-0002-0422-4277

Funding

National Natural Science Foundation of China (National Science Foundation of China) 62174152National Natural Science Foundation of China (National Science Foundation of China) 62374159National Natural Science Foundation of China (National Science Foundation of China) 62422409Youth Innovation Promotion Association of the Chinese Academy of Sciences (Youth Innovation Promotion Association CAS) 2020115
6 · The paper itself

Abstract

Portable biosensors mainly focus on detecting biomarkers in biofluids but neglect the abundant skin biomarkers on the stratum corneum, which are associated with the functionality and integrity of the skin barrier. Here, we propose a sensing patch designed for direct sampling and in situ quantification of epidermal serine, an important biomarker for skin healthcare. The patch consists of a porous hydrogel for serine diffusion and ion conduction, and a molecular imprinted polymer-based electrochemical serine sensor. By integrating with a customized handheld serine tester, the serine sensing system enables in situ measurement of epidermal serine levels. We demonstrate the application of this serine sensing system in assessing the moisturizing effect of a skincare product and tracking the recovery progress of skin barrier function in a patient with atopic dermatitis. Our work opens up a potential application scenario for portable biosensors in personalized skin healthcare.

Indexed as

Biosensing TechniquesEpidermisSerineSkin CareBiomarkersDermatitis, AtopicElectrochemical TechniquesHumansHydrogelsMolecular ImprintingSkinBiomarkersHydrogelsSerine

Identifiers

PMID40102486
PMCPMC11920223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.