Evidence map›Paper›PMID 40102459›Full record

ArticleScientific reports2025

Identification of methionine metabolism related prognostic model and tumor suppressive functions of BHMT in hepatocellular carcinoma.

Wenli Liu, Kaiheng Hu, Yaqing Fu, Tianmin Zhou, Qingmei Zhong, Wu Wang, Yang Gui, Ping Zhang, Di Yao, Xiaohong Yang and 4 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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14 authors.

Wenli Liu *Department of Pathology, Infectious Diseases Hospital of Nanchang University, Nanchang, 330001, Jiangxi, China.
Kaiheng Hu *Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Yaqing FuQueen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
Tianmin ZhouDepartment of Pathology, Infectious Diseases Hospital of Nanchang University, Nanchang, 330001, Jiangxi, China.
Qingmei ZhongDepartment of Pathology, Infectious Diseases Hospital of Nanchang University, Nanchang, 330001, Jiangxi, China.
Wu WangDepartment of Pathology, Infectious Diseases Hospital of Nanchang University, Nanchang, 330001, Jiangxi, China.
Yang GuiDepartment of Pathology, Infectious Diseases Hospital of Nanchang University, Nanchang, 330001, Jiangxi, China.
Ping ZhangDepartment of Pathology, Infectious Diseases Hospital of Nanchang University, Nanchang, 330001, Jiangxi, China.
Di YaoDepartment of Pathology, Infectious Diseases Hospital of Nanchang University, Nanchang, 330001, Jiangxi, China.
Xiaohong YangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Weifeng ZhuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Zhuoqi LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. liuzhuoqi@ncu.edu.cn.
Daya LuoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. luodaya@ncu.edu.cn.
Yingqun XiaoDepartment of Pathology, Infectious Diseases Hospital of Nanchang University, Nanchang, 330001, Jiangxi, China. xiaoyq2008@126.com.

Funding

Health Commission of Jiangxi Province 2021-4-0132Health Commission of Jiangxi Province 2022-1-1521Science and Technology Bureau of Nanchang Municipality 2022-KJZC-015
6 · The paper itself

Abstract

Given the resistance to conventional treatments and limitations of immune checkpoint blockade therapy in hepatocellular carcinoma (HCC), it is imperative to explore novel prognostic models and biomarkers. The dependence of cancer cell on exogenous methionine, known as Hoffman effect, is a hallmark of HCC, with numerous studies reporting a strong correlation between methionine metabolism and tumor development. Betaine-homocysteine S-methyltransferase (BHMT), a critical component of methionine metabolism pathway, has polymorphisms linking to poor prognosis in multiple cancers. Nevertheless, there is little literature regarding the relationship between methionine metabolism and incidence, mortality of HCC, as well as the function of BHMT in HCC progression. In this study, by analyzing multiple datasets, we constructed a methionine metabolism-related prognostic model and thoroughly investigated the influence of BHMT on the prognosis of HCC. Bioinformatics analysis revealed a marked decrease in BHMT expression in HCC, which was linked to adverse clinical outcomes. CIBERSORT results suggest that BHMT promotes infiltration of M1 macrophages. Our results suggest its potential as an ideal prognostic biomarker for anti PD-L1 immunotherapy. In summary, this study innovatively provides first methionine metabolism-related prognostic model and unveils the tumor suppressive function of BHMT in HCC, providing potential mechanism by which BHMT exert its function.

Indexed as

Betaine-Homocysteine S-MethyltransferaseCarcinoma, HepatocellularLiver NeoplasmsMethionineBiomarkers, TumorGene Expression Regulation, NeoplasticHumansPrognosisBetaine-Homocysteine S-MethyltransferaseBiomarkers, TumorMethionineBHMTHepatocellular carcinomaImmunotherapyLipid metabolismMethionine metabolismTumor microenvironment

Identifiers

PMID40102459
PMCPMC11920202

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