ArticleScientific reports2025
Predictors of optimal angiographic lesion outcomes in drug-coated balloon treatment for de novo coronary artery disease.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04619277 (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion
Who cites it
3 citing papers in PubMed.
- Drug-Coated Balloons in Coronary Bifurcation Disease: A State-of-the-Art Review.Journal of personalized medicine · 2026Review
- Comparative prognostic value of diameter stenosis, Murray law-based quantitative flow ratio and radial wall strain after drug-coated balloon in de novo coronary lesions.BMC cardiovascular disorders · 2026Article
- Intravascular imaging-guided drug-coated balloon treatment for coronary artery disease:Evidence and practice.Indian heart journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Drug-coated balloon (DCB) treatment is an emerging strategy for de novo coronary artery disease (CAD), but procedural optimization remains uncertain. This study analyzed 317 patients who underwent DCB-based intervention for de novo CAD and angiographic follow-up: SR (successful, stent-like result: diameter stenosis < 20% at follow-up angiography, n = 84, 93 lesions) and Non-SR (n = 224, 358 lesions) groups. Baseline clinical and lesion characteristics were similar, except that SR lesions had larger diameter. In SR lesions, specialty balloons were more frequently utilized (p = 0.025), and maximal balloon diameter and balloon-to-artery ratio were significantly greater compared to Non-SR lesions (p < 0.001 and p = 0.008). At a median 8-month follow-up, SR lesions exhibited larger minimal luminal diameter (MLD) and lower late lumen loss, with negative values indicating positive vessel remodeling. In multivariate analysis, post-DCB MLD (odds ratio 1.17 per 0.1 mm increase, p < 0.001) and balloon-to-artery ratio (odds ratio 1.43 per 0.1 increase, p = 0.002) were independent predictors for successful angiographic outcomes with thresholds of 1.95 mm for post-DCB MLD and 1.13 for balloon-to-artery ratio. In 47 patients, IVUS guidance resulted in balloon-to-artery ratio of 1.23 as calculated by QCA. The study demonstrated the importance of achieving maximal post-DCB MLD through aggressive lesion predilation, underscoring the need for refining procedural strategies. NCT04619277 (Impact of Drug-Coated Balloon Treatment in De Novo Coronary Lesion).
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Registered trials
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