ArticleScientific reports2025
The association between dietary acid load and indices of insulin resistance.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- TyG-BMI as a Marker of Metabolic Status and Its Association with Bone Quality and Mineral Metabolism: A Sex-Specific Analysis.Journal of clinical medicine · 2026Article
- Association of dietary acid load with abdominal adiposity based on traditional and novel anthropometric indices.Journal of health, population, and nutrition · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of diet-induced acid-base imbalance in insulin resistance (IR) and related cardiometabolic abnormalities has attracted considerable attention. This study sought to investigate the association between dietary acid load and IR indices among Iranian adults. The study included 6,531 participants, with dietary acid load estimated using a validated questionnaire which comprised 65 food frequency items. The IR indices assessed included: Triglyceride to high-density lipoprotein (TG: HDL), Metabolic score for insulin resistance (METS-IR), Triglyceride Glucose-Body mass index (TyG-BMI), Triglyceride glucose (TyG), and Triglyceride glucose-waist circumference (TyG-WC). The results revealed that all IR indices were significantly higher in participants positioned in the top tertiles of dietary acid load as opposed to those in the lowest, with a notable increasing trend (p < 0.001). Using a crude model, there was a significant positive association between TG: HDL, TyG, TyG-WC, TyG-BMI, and METS-IR with dietary acid load (p < 0.001). However, in the fully adjusted model, only TyG and TyG-WC remained significant (OR=1.16, 95% CI: 1.04-1.30, and OR=1.69, 95% CI: 1.51-1.90, respectively). In summary dietary acid load is significantly associated with IR indices, with TyG-WC showing the strongest relationship.
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