Evidence map›Paper›PMID 40102442›Full record

ArticleScientific reports2025

Functionality of Toxoplasma gondii antibodies in a population of Beninese pregnant women exposed to malaria.

Mariama Souffou, Célia Dechavanne, Zaineb Kammoun, Firmine Viwami, Isabelle Gaugué, Naima Beldjoudi, Sébastien Dechavanne, Nawal Sare, André Garcia, Magalie Dambrun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mariama SouffouUniversité Paris Cité, MERIT, IRD, Inserm, Paris, Paris, F-75006, France.
Célia DechavanneUniversité Paris Cité, MERIT, IRD, Inserm, Paris, Paris, F-75006, France.
Zaineb KammounUniversité Paris Cité, Cibles Thérapeutiques et Conception de Médicaments (CiTCoM), CNRS, Paris, France.
Firmine ViwamiUniversité Paris Cité, MERIT, IRD, Inserm, Paris, Paris, F-75006, France.
Isabelle GauguéUniversité Paris Cité, MERIT, IRD, Inserm, Paris, Paris, F-75006, France.
Naima BeldjoudiEpidemiology and Clinical Research Department, GH Paris Nord Val de Seine, Assistance Publique - Hôpitaux de Paris, Paris, France.
Sébastien DechavanneUniversité Paris Cité, MERIT, IRD, Inserm, Paris, Paris, F-75006, France.
Nawal SareCentre d'Etude et de Recherche sur les Pathologies Associées à la Grossesse et à L'Enfance, Cotonou, Bénin.
André GarciaUniversité Paris Cité, MERIT, IRD, Inserm, Paris, Paris, F-75006, France.
Magalie Dambrun *Université Paris Cité, MERIT, IRD, Inserm, Paris, Paris, F-75006, France. magalie.dambrun@ird.fr.
Florence Migot-Nabias *Université Paris Cité, MERIT, IRD, Inserm, Paris, Paris, F-75006, France. florence.migot-nabias@ird.fr.

Funding

Agence Nationale de la Recherche ANR-19-CE44-0004, IgNameAP-HP Nord et Université Paris Cité DHU 'Risks and pregnancy", PRIDE 2016, TOXODIAGConseil Départemental de Mayotte PhD scholarshipInstitut de Médecine et d'Epidémiologie Appliquée grant 0602DIRmba, 2018, CoaLaUniversité Paris Cité, France IdEx 2019 "Dynamique Recherche", PlasDCty
6 · The paper itself

Abstract

Plasmodium falciparum and Toxoplasma gondii are two apicomplexan parasites that can lead to severe complications for the newborn when contracted during pregnancy. This study explores the cross-reactivity of antibodies specific to both pathogens in pregnant women, exposed or not to malaria. The antibody response against full-length recombinant antigens from P. falciparum (PfAMA1, Pfs48/45) and T. gondii (TgAMA1, TgSAG1, TgGRA7), selected for their strong immunogenicity, was analysed on 150 plasma samples from women residing in Benin or France. The antibody functionality was assessed using P. falciparum in vitro Growth Inhibition Assay (GIA). As the main results, toxoplasmosis seropositive women with an ongoing P. falciparum infection better inhibited P. falciparum invasion compared to toxoplasmosis seronegative women (34.6% vs. 17.2%, p ≤ 0.01). Women with positive serologies for both parasites presented a significantly higher inhibition of P. falciparum invasion compared to those only seropositive for malaria (coef = 6.27, p = 0.076) in reference with double-negative women (coef = 11.35, p = 0.001). These data suggest that plasma samples containing anti-T. gondii IgG may contribute reducing the development of P. falciparum parasites. This study provides insight into the immune dynamics of the co-infection by these two apicomplexans with potential implications for developing cross-protective vaccines and therapies.

Indexed as

Antibodies, ProtozoanMalaria, FalciparumPregnancy Complications, ParasiticToxoplasmaToxoplasmosisAdultAntigens, ProtozoanBeninCross ReactionsFemaleHumansImmunoglobulin GPlasmodium falciparumPregnancyYoung AdultAntibodies, ProtozoanAntigens, ProtozoanImmunoglobulin G

Identifiers

PMID40102442
PMCPMC11920409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.