Evidence map›Paper›PMID 40102426›Full record

ArticleNature communications2025

The primate-specific Nedd4-1(NE) localizes to late endosomes in response to amino acids to suppress autophagy.

G Kefalas, A Priya, A Astori, A Persaud, L Jing, A M Sydor, H H Y Yao, N Warner, Y Zhang, J H Brumell and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

G KefalasCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-6477-9688
A PriyaCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-8673-5371
A AstoriPrincess Margaret Cancer Centre, University Health Network, and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
A PersaudCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
L JingPrincess Margaret Cancer Centre, University Health Network, and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
A M SydorCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-3585-0446
H H Y YaoCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-6723-6267
N WarnerCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-9207-5979
Y ZhangHuman Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
J H BrumellCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-5802-7789
A M MuiseCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-9624-3346
S SariDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Gazi University, Ankara, Turkey.
H C SuHuman Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5582-9110
M J LenardoClinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
W H A KahrCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-2832-7158
B RaughtPrincess Margaret Cancer Centre, University Health Network, and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
D RotinCell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada. drotin@sickkids.ca.ORCID http://orcid.org/0000-0001-5201-6280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ubiquitin ligase Nedd4 (Nedd4-1), comprised of C2-WW

Indexed as

Amino AcidsAutophagyEndosomesNedd4 Ubiquitin Protein LigasesAnimalsAutophagosomesEndosomal Sorting Complexes Required for TransportHEK293 CellsHeLa CellsHumansLysosomesMechanistic Target of Rapamycin Complex 1PrimatesUbiquitinationVesicular Transport ProteinsAmino AcidsEndosomal Sorting Complexes Required for TransportMechanistic Target of Rapamycin Complex 1Nedd4 protein, humanNedd4 Ubiquitin Protein LigasesVesicular Transport Proteins

Identifiers

PMID40102426
PMCPMC11920435

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.