Evidence map›Paper›PMID 40102385›Full record

ArticleNature communications2025

Unraveling the neurophysiological correlates of phase-specific enhancement of motor memory consolidation via slow-wave closed-loop targeted memory reactivation.

Judith Nicolas, Bradley R King, David Lévesque, Latifa Lazzouni, Gaëlle Leroux, David Wang, Nir Grossman, Stephan P Swinnen, Julien Doyon, Julie Carrier and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Judith NicolasDepartment of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7142-1449
Bradley R KingDepartment of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-3010-8755
David LévesqueCenter for Advanced Research in Sleep Medicine, Montreal, QC, Canada.
Latifa LazzouniMcConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Gaëlle LerouxUniversité Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, 69500, Bron, France.ORCID http://orcid.org/0000-0003-2729-4945
David WangElemind Technologies Inc Massachusetts Institute of Technology, Cambridge, MA, USA.
Nir GrossmanFaculty of Medicine, Department of Brain Sciences, Imperial College London, London, UK.
Stephan P SwinnenDepartment of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-7173-435X
Julien DoyonMcConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-3788-4271
Julie CarrierCenter for Advanced Research in Sleep Medicine, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-5311-2370
Geneviève AlbouyDepartment of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, Leuven, Belgium. Genevieve.albouy@kuleuven.be.ORCID http://orcid.org/0000-0002-5437-023X

Funding

Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 1524218NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G099516NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G0B1419N
6 · The paper itself

Abstract

Memory consolidation can be enhanced during sleep using targeted memory reactivation (TMR) and closed-loop (CL) acoustic stimulation on the up-phase of slow oscillations (SOs). Here, we test whether applying TMR at specific phases of the SOs (up vs. down vs. no reactivation) can influence the behavioral and neural correlates of motor memory consolidation in healthy young adults. Results show that up- (as compared to down-) state cueing results in greater performance improvement. Sleep electrophysiological data indicate that up- (as compared to down-) stimulated SOs exhibits higher amplitude and greater peak-nested sigma power. Task-related functional magnetic resonance images reveal that up-state cueing strengthens activity in - and segregation of - striato-motor and hippocampal networks; and that these modulations are related to the beneficial effect of TMR on sleep features and performance. Overall, these findings highlight the potential of CL-TMR to induce phase-specific modulations of motor performance, sleep oscillations and brain responses during motor memory consolidation.

Indexed as

Memory ConsolidationAcoustic StimulationAdultBrainCuesElectroencephalographyFemaleHippocampusHumansMagnetic Resonance ImagingMaleSleepYoung Adult

Identifiers

PMID40102385
PMCPMC11920436

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.