Evidence map›Paper›PMID 40102383›Full record

ArticleSignal transduction and targeted therapy2025

Photodynamic gel-bombs enhance tumor penetration and downstream synergistic therapies.

Xiaole Bai, Fanliang Meng, Xuejiao Wang, Linyun He, Chao Fan, Liangjie Tian, Yangning Zhang, Jiahao Pan, Qun Wu, Xiangrong Hao and 4 more

Abstract read
In one paragraph

Article in Signal transduction and targeted therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaole Bai *Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, 510515, Guangzhou, P.R. China.
Fanliang Meng *Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, P.R. China.
Xuejiao WangCancer Research Institute, Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P.R. China.
Linyun HeCancer Research Institute, Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P.R. China.
Chao FanCancer Research Institute, Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P.R. China.
Liangjie TianGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, 510515, Guangzhou, P.R. China.
Yangning ZhangCancer Research Institute, Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P.R. China.
Jiahao PanCancer Research Institute, Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P.R. China.
Qun WuCancer Research Institute, Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P.R. China.
Xiangrong HaoCancer Research Institute, Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P.R. China.
Ying WangCancer Research Institute, Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P.R. China.
Bo-Feng ZhuGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, 510515, Guangzhou, P.R. China. zhubofeng7372@126.com.
Jun-Bing FanCancer Research Institute, Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University, 510515, Guangzhou, P.R. China. fjb2012@mail.ipc.ac.cn.ORCID 0000-0002-3273-934X
Bin CongGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, 510515, Guangzhou, P.R. China. cong6406@hebmu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22075127National Natural Science Foundation of China (National Science Foundation of China) 22275080National Natural Science Foundation of China (National Science Foundation of China) 82293650National Natural Science Foundation of China (National Science Foundation of China) 82293651National Natural Science Foundation of China (National Science Foundation of China) 82293652
6 · The paper itself

Abstract

Nanoparticle-based drug delivery system remains a significant challenge in the current treatment of solid tumors, primarily due to their limited penetration capabilities. Herein, we successfully engineer photodynamic gel-bombs (DCM@OPR) capable of penetrating deeply into tumor tissues utilizing the photodynamic-triggered explosive energy and receptor-mediated transcytosis, significantly enhancing the therapeutic efficacy of breast cancer. The photodynamic gel-bombs were fabricated by loading powerful components of chlorin e6 and MnO

Indexed as

Breast NeoplasmsDoxorubicinDrug Delivery SystemsNanoparticlesPhotochemotherapyPorphyrinsAnimalsCell Line, TumorChlorophyllidesFemaleGelsHumansManganese CompoundsMiceOxidesPhotosensitizing AgentsChlorophyllidesDoxorubicinGelsManganese CompoundsOxidesPhotosensitizing AgentsphytochlorinPorphyrins

Identifiers

PMID40102383
PMCPMC11920195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.