Evidence map›Paper›PMID 40102379›Full record

Trial reportNature communications2025

Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: a randomized controlled trial.

Lishi Deng, Steff Taelman, Matthew R Olm, Laeticia Celine Toe, Eva Balini, Lionel Olivier Ouédraogo, Yuri Bastos-Moreira, Alemayehu Argaw, Kokeb Tesfamariam, Erica D Sonnenburg and 10 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03533712 (Effect of a Fortified Balanced Energy-Protein Supplement on Birth Outcome and Child Growth in Houndé District, Burkina Faso.), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03533712 phase4completednot on this map

Effect of a Fortified Balanced Energy-Protein Supplement on Birth Outcome and Child Growth in Houndé District, Burkina Faso.

TypeinterventionalSponsorUniversity GhentRan2019 to 2022Enrolled1,788ConditionsSmall for Gestational Age at Delivery, Low Birth Weight, Prematurity, Infant MalnutritionArmsFortified balanced energy-protein (BEP) supplement, Fe and folic acid supplement
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lishi Deng *Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium.
Steff Taelman *BIOBIX, Department of Data Analysis and Mathematical Modelling, Ghent University, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0002-2685-4130
Matthew R OlmDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5540-350X
Laeticia Celine ToeDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0002-4615-5388
Eva BaliniBioLizard nv, 9000, Ghent, Belgium.
Lionel Olivier OuédraogoDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0002-2729-6994
Yuri Bastos-MoreiraDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium.
Alemayehu ArgawDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium.
Kokeb TesfamariamDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium.
Erica D SonnenburgDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8379-005X
Giles T Hanley-CookDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium.
Moctar OuédraogoAgence de Formation de Recherche et d'Expertise en Santé pour l'Afrique (AFRICSanté), Bobo-Dioulasso, Burkina Faso.ORCID http://orcid.org/0000-0002-1521-0532
Rasmané GanabaAgence de Formation de Recherche et d'Expertise en Santé pour l'Afrique (AFRICSanté), Bobo-Dioulasso, Burkina Faso.
Wim Van CriekingeBIOBIX, Department of Data Analysis and Mathematical Modelling, Ghent University, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0003-2971-5539
Lieven HuybregtsDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium.
Michiel StockKERMIT, Department of Data Analysis and Mathematical Modelling, Ghent University, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0003-0903-6061
Patrick KolsterenDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium.
Justin L SonnenburgDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Carl LachatDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium. carl.lachat@ugent.be.ORCID http://orcid.org/0000-0002-1389-8855
Trenton Dailey-ChwalibógDepartment of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000, Ghent, Belgium. Trenton@Dailey-Chwalibog.com.ORCID http://orcid.org/0000-0002-8204-4925

Funding

Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1175213NIH HHS S10 OD026929
6 · The paper itself

Abstract

Balanced energy-protein (BEP) supplementation during pregnancy and lactation can improve birth outcomes and infant growth, with the gut microbiome as a potential mediator. The MISAME-III randomized controlled trial (ClinicalTrial.gov: NCT03533712) assessed the effect of BEP supplementation, provided during pregnancy and the first six months of lactation, on small-for-gestational age prevalence and length-for-age Z-scores at six months in rural Burkina Faso. Nested within MISAME-III, this sub-study examines the impact of BEP supplementation on maternal and infant gut microbiomes and their mediating role in birth outcomes and infant growth. A total of 152 mother-infant dyads (n = 71 intervention, n = 81 control) were included for metagenomic sequencing, with stool samples collected at the second and third trimesters, and at 1-2 and 5-6 months postpartum. BEP supplementation significantly altered maternal gut microbiome diversity, composition, and function, particularly those with immune-modulatory properties. Pathways linked to lipopolysaccharide biosynthesis were depleted and the species Bacteroides fragilis was enriched in BEP-supplemented mothers. Maternal BEP supplementation also accelerated infant microbiome changes and enhanced carbohydrate metabolism. Causal mediation analyses identified specific taxa mediating the effect of BEP on birth outcomes and infant growth. These findings suggest that maternal supplementation modulates gut microbiome composition and influences early-life development in resource-limited settings.

Indexed as

Carbohydrate MetabolismDietary ProteinsDietary SupplementsGastrointestinal MicrobiomeAdultBurkina FasoFecesFemaleHumansInfantInfant, NewbornLactationMaleMaternal Nutritional Physiological PhenomenaPregnancyDietary Proteins

Identifiers

PMID40102379
PMCPMC11920048

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.